Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J. Abdallah, P. Abreu, W. Adam, P. Adzic, T. Albrecht, et al.. Measurement of the Tau Lepton Polarisation at LEP2. Physics Letters B, 2008, 659, pp.65-73. ⟨10.1016/j.physletb.2007.10.022⟩. ⟨in2p3-00177782⟩
  • E. Testa, M. Bajard, M. Chevallier, D. Dauvergne, F. Le Foulher, et al.. Monitoring the Bragg peak location of 73 MeV/u carbon ions by means of prompt γ-ray measurements. Applied Physics Letters, 2008, 93, pp.093506. ⟨hal-01920991⟩
  • S. Rai Choudhury, A.S. Cornell, Naveen Gaur. B \to K_1(1270) (\to \rho K) \ell^+ \ell^- in LEET. European Physical Journal C: Particles and Fields, 2008, 58, pp.251-259. ⟨10.1140/epjc/s10052-008-0752-x⟩. ⟨in2p3-00170283⟩
  • T. Sousbie, H.M. Courtois, G. Bryan, J. Devriendt. MoLUSC: A MOck Local Universe Survey Constructor. The Astrophysical Journal, 2008, 678, pp.569-577. ⟨10.1086/526507⟩. ⟨in2p3-00293961⟩
  • M. Tribet, N. Toulhoat, N. Moncoffre, C. Jegou, G. Leturcq, et al.. Leaching of a zirconolite ceramic waste-form under proton and He2+ irradiation. Radiochimica Acta, 2008, 96, pp.619-624. ⟨10.1524/ract.2008.1545⟩. ⟨in2p3-00346855⟩
  • J.-P. Thomas, A. Bejjani, B. Nsouli, A. Gardon, J.-M. Chovelon. Investigation of norflurazon pesticide photodegradation using plasma desorption time-of-flight mass spectrometry analysis. Rapid Communications in Mass Spectrometry, 2008, 22, pp.2429-2435. ⟨10.1002/rcm.3628⟩. ⟨in2p3-00321912⟩
  • H. Kraus, E. Armengaud, M. Bauer, I. Bavykina, Alain Benoit, et al.. EURECA - The Future of Cryogenic Dark Matter Detection in Europe. Dark Energy and Dark Matter: Observations, Experiments and Theories, 2008, Lyon, France. pp.249-255, ⟨10.1051/eas/0936035⟩. ⟨in2p3-00408920⟩
  • M. Kibler. Generalized spin bases for quantum chemistry and quantum information. Collection of Czechoslovak Chemical Communications, 2008, 73, pp.1281-1298. ⟨10.1135/cccc20081281⟩. ⟨in2p3-00295347⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Observation of the B_c Meson in the Exclusive Decay B_c \to J/\psi \pi. Physical Review Letters, 2008, 101, pp.012001. ⟨10.1103/PhysRevLett.101.012001⟩. ⟨in2p3-00259690⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Simultaneous measurement of the ratio B(t->Wb)/B(t->Wq) and the top quark pair production cross section with the D0 detector at sqrt(s)=1.96 TeV. Physical Review Letters, 2008, 100, pp.192003. ⟨10.1103/PhysRevLett.100.192003⟩. ⟨in2p3-00203403⟩

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