Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • E. Testa, M. Bajard, M. Chevallier, D. Dauvergne, F. Le Foulher, et al.. Dose profile monitoring with carbon ions by means of prompt-gamma measurements. Seventh International Symposium Swift Heavy Ion in Matter - SHIM2008, 2008, Lyon, France. ⟨in2p3-00408905⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Observation of the doubly strange b baryon Omega_b-. Physical Review Letters, 2008, 101, pp.232002. ⟨10.1103/PhysRevLett.101.232002⟩. ⟨in2p3-00315793⟩
  • Erwan Verron, Andri Andriyana, Malik Aït-Bachir. Predicting fatigue crack nucleation in rubber with the Eshelby stress tensor. EUROMECH Colloquium 502. Reinforced elastomers: fracture mechanics, statistical physics and numerical simulation, 2008, Dresden, Germany. ⟨hal-01008669⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of the ratio of the p\bar{p}\to W+c-jet cross section to the inclusive p\bar{p}\to W+jets cross section. Physics Letters B, 2008, 666, pp.23-30. ⟨10.1016/j.physletb.2008.06.067⟩. ⟨in2p3-00293667⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for Supersymmetry in di-Photon final states at \sqrt{s} = 1.96 TeV. Physics Letters B, 2008, 659, pp.856-863. ⟨10.1016/j.physletb.2007.12.006⟩. ⟨in2p3-00182822⟩
  • E. Testa, M. Bajard, M. Chevallier, D. Dauvergne, F. Le~foulher, et al.. Detection of Prompt Gamma Rays to Monitor Hadrontherapy. IEEE Nuclear Science Symposium / Medical Imaging Conference, 2008, Unknown, Unknown Region. ⟨hal-01920988⟩
  • M. Morjean, D. Jacquet, J.L. Charvet, A. L'Hoir, M. Laget, et al.. Fission time measurements: a new probe into super-heavy element stability. Physical Review Letters, 2008, 101, pp.072701. ⟨10.1103/PhysRevLett.101.072701⟩. ⟨in2p3-00289928⟩
  • H.T. Cho, A.S. Cornell, J. Doukas, W. Naylor. Fermion excitations of a tense brane black hole. Physical Review D, 2008, 77, pp.041502. ⟨10.1103/PhysRevD.77.041502⟩. ⟨in2p3-00184816⟩
  • P. Achard, O. Adriani, M. Aguilar-Benitez, M. van den Akker, J. Alcaraz, et al.. Study of the solar anisotropy for cosmic ray primaries of about 200 GeV energy with the L3+C muon detector. Astronomy & Astrophysics - A&A, 2008, 488, pp.1093-1100. ⟨10.1051/0004-6361:200809634⟩. ⟨in2p3-00329809⟩
  • S. Lapuerta, N. Bérerd, N. Moncoffre, N. Millard-Pinard, H. Jaffrézic, et al.. The influence of relative humidity on iron corrosion under proton irradiation. Journal of Nuclear Materials, 2008, 375, pp.80-85. ⟨10.1016/j.jnucmat.2007.10.011⟩. ⟨in2p3-00321596⟩

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