Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • S. Chatrchyan, G. Hmayakyan, V. Khachatryan, A. M. Sirunyan, W. Adam, et al.. The CMS experiment at the CERN LHC. Journal of Instrumentation, 2008, 3, pp.S08004. ⟨10.1088/1748-0221/3/08/S08004⟩. ⟨in2p3-00311605⟩
  • H.T. Cho, A.S. Cornell, J. Doukas, W. Naylor. Bulk dominated fermion emission on a Schwarzschild background. Physical Review D, 2008, 77, pp.016004. ⟨10.1103/PhysRevD.77.016004⟩. ⟨in2p3-00172422⟩
  • E. Olivieri, L. Berge, M. Chapellier, S. Collin, Y. Dolgorouky, et al.. Modelling of the surface-event identification mechanism in Ge detectors equipped with NbSi thin films. Journal of Low Temperature Physics, 2008, 151, pp.884-890. ⟨10.1007/s10909-008-9760-3⟩. ⟨in2p3-00854123⟩
  • J. Tabet, S. Eden, F. Gobet, B. Farizon, M. Farizon, et al.. Absolute partial cross-sections for the destruction channels of H_2 and H_3^+ in collisions with helium atoms at 50 and 60 keV/amu. International Journal of Mass Spectrometry, 2008, 272, pp.48-56. ⟨10.1016/j.ijms.2007.12.014⟩. ⟨in2p3-00274350⟩
  • Claire-Emilie Vaudey, N. Toulhoat, Nathalie Moncoffre, Nicolas Bererd, Louis Raimbault, et al.. Thermal behaviour of chlorine in nuclear graphite at a microscopic scale. Journal of Nuclear Materials, 2008, 395 (1-3), pp.62-68. ⟨10.1016/j.jnucmat.2009.09.018⟩. ⟨hal-00819182⟩
  • X. Artru, C. Ray. Interference and Shadow Effects in the Production of Light by Charged Particles in Optical Fibers. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2008, 266, pp.3725-3732. ⟨10.1016/j.nimb.2008.03.083⟩. ⟨in2p3-00260233⟩
  • J. Abdallah, P. Abreu, W. Adam, P. Adzic, T. Albrecht, et al.. Higgs boson searches in CP-conserving and CP-violating MSSM scenarios with the DELPHI detector. Erratum to: Eur. Phys. J. C 54, 1-35 (2008). European Physical Journal C: Particles and Fields, 2008, 56, pp.165-170. ⟨10.1140/epjc/s10052-008-0647-x⟩. ⟨in2p3-00308743⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for the lightest scalar top quark in events with two leptons in p\bar p collisions at \sqrt{s} = 1.96 TeV. Physics Letters B, 2008, 659, pp.500-508. ⟨10.1016/j.physletb.2007.11.086⟩. ⟨in2p3-00164647⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for W' bosons decaying to an electron and a neutrino with the D0 detector. Physical Review Letters, 2008, 100, pp.031804. ⟨10.1103/PhysRevLett.100.031804⟩. ⟨in2p3-00179901⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for scalar leptoquarks and T-odd quarks in the acoplanar jet topology using 2.5 fb-1 of ppbar collision data at sqrt(s)=1.96 TeV. Physics Letters B, 2008, 668, pp.357-363. ⟨10.1016/j.physletb.2008.09.014⟩. ⟨in2p3-00309002⟩

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