Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8785 documents

  • G. Brooijmans, A. Buckley, S. Caron, A. Falkowski, B. Fuks, et al.. Les Houches 2019 Physics at TeV Colliders: New Physics Working Group Report. 11th Les Houches Workshop on Physics at TeV Colliders, Jun 2019, Les Houches, France. ⟨hal-02507621⟩
  • Delphine Vernos, P. Rocchi, Marie-ThĂ©rèse Aloy, F. Lux, O. Tillement, et al.. Novel generation of ultrasmall high Z tailored nanoparticles for tumor cell radiosensitization. Nanohybrid XVI: Annual Conference of the Architects of Nanohybrid Compounds: Toward Material and Biological Applications, Jun 2019, Porquerolles island, France. ⟨hal-02355884⟩
  • Nils Krah, Simon Rit. Optimized conversion from CT numbers to proton relative stopping power based on proton radiography and scatter corrected cone-beam CT images. The Fifteenth International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, Jun 2019, Philadelphia, United States. pp.96, ⟨10.1117/12.2534898⟩. ⟨hal-02142832⟩
  • M. Garbacz, G. Battistoni, M. Durante, J. Gajewski, Nils Krah, et al.. Proton Therapy Treatment Plan Verification in CCB Krakow Using Fred Monte Carlo TPS Tool. World Congress on Medical Physics and Biomedical Engineering 2018, pp.783-787, 2019, 978-981-10-9035-6. ⟨10.1007/978-981-10-9035-6_144⟩. ⟨hal-02056752⟩
  • E. Armengaud, C. Augier, A.S. Barabash, F. Bellini, A. Benoit, et al.. Precise measurement of 2ν2\beta decay of ^{100}Mo with Li_2MoO_4 low temperature detectors: Preliminary results. Matrix Elements for the Double-beta-decay EXperiments, May 2019, Prague, Czech Republic. pp.020005, ⟨10.1063/1.5130966⟩. ⟨hal-02394748⟩
  • Pascaline Delalande, Philippe Lalle, Luc Massou, Carole Nocera-Picand, Nathalie Younes. Quels usages d’un dispositif de formation continue en ligne Ă  la pĂ©dagogie universitaire ? Le cas du MOOC « Se former pour enseigner dans le supĂ©rieur ». Distances et MĂ©diations des Savoirs, 2019, 26, pp.[En ligne]. ⟨10.4000/dms.3532⟩. ⟨halshs-03085395⟩
  • Rainer Stiele, Wanda Maria Alberico, Andrea Beraudo, Renan Câmara Pereira, Pedro Costa, et al.. Aspects of isentropic trajectories in chiral effective models. 6th FAIR next generation scientists workshop 2019, May 2019, Genova, Italy. pp.012043, ⟨10.1088/1742-6596/1667/1/012043⟩. ⟨hal-02317310⟩
  • Nicolas Baillot d'Étivaux, JĂ©rĂ´me Margueron, Sebastien Guillot, Natalie Webb, MĂ rcio Catelan, et al.. Constraining the equation of state of dense nuclear matter using thermal emission of neutron stars. 6th FAIR next generation scientists workshop 2019, May 2019, Genova, Italy. pp.012001, ⟨10.1088/1742-6596/1667/1/012001⟩. ⟨hal-03047523⟩
  • Pierros Ntelis, Adam James Hawken, Stephanie Escoffier, Anne Ealet, Andre Tilquin. Cosmological constraints from cosmic homogeneity. 2019. ⟨hal-02129901⟩
  • Alina Goldkuhle, Christoph Fransen, Alfred Dewald, Navin Alahari, Marcel Beckers, et al.. Preliminary results of lifetime measurements in neutron-rich ^{53}Ti. 4th International Conference on Nuclear Structure and Dynamics, May 2019, Venice, Italy. pp.01022, ⟨10.1051/epjconf/201922301022⟩. ⟨hal-02409992⟩

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