Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Yasmine Ali, Caterina Monini, Jean Michel LĂ©tang, Etienne Testa, Lydia Maigne, et al.. Benchmarking micro- and nanodosimetry spectra and free radicals simulated with GEANT4DNA, LQD, PHYCHEML, CHEM for ion beams. PTCOG 58, Jun 2019, Manchester, United Kingdom. ⟨hal-02308735⟩
    • Brent Huisman, Etienne Testa, David Sarrut. Analytical and Monte-Carlo modeling of Multi-Parallel Slit and Knife-Edge Slit Prompt Gamma Cameras. PTCOG 58, Jun 2019, Manchester, United Kingdom. ⟨hal-03128213⟩
    • Yuemeng Feng, Mattia Fontana, Ane Etxebeste, Denis Dauvergne, Jean Michel LĂ©tang, et al.. A maximum-a-posteriori EM reconstruction method based on total variation regularization for Compton camera imaging. 58th Annual Conference of The Particle Therapy Co-Operative Group (PTCOG58), Jun 2019, Manchester, United Kingdom. ⟨hal-02359539⟩
    • G. Brooijmans, A. Buckley, S. Caron, A. Falkowski, B. Fuks, et al.. Les Houches 2019 Physics at TeV Colliders: New Physics Working Group Report. 11th Les Houches Workshop on Physics at TeV Colliders, Jun 2019, Les Houches, France. ⟨hal-02507621⟩
    • Jayde Livingstone, A. Etxebeste, Denis Dauvergne, Mattia Fontana, Marie-Laure Gallin-Martel, et al.. Fast-prompt gamma imaging for the online monitoring of the ion range in hadron therapy. PTCOG 58, Jun 2019, Manchester, United Kingdom. . ⟨hal-02355263⟩
    • Delphine Vernos, P. Rocchi, Marie-ThĂ©rèse Aloy, F. Lux, O. Tillement, et al.. Novel generation of ultrasmall high Z tailored nanoparticles for tumor cell radiosensitization. Nanohybrid XVI: Annual Conference of the Architects of Nanohybrid Compounds: Toward Material and Biological Applications, Jun 2019, Porquerolles island, France. ⟨hal-02355884⟩
    • Nils Krah, Simon Rit. Optimized conversion from CT numbers to proton relative stopping power based on proton radiography and scatter corrected cone-beam CT images. The Fifteenth International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, Jun 2019, Philadelphia, United States. pp.96, ⟨10.1117/12.2534898⟩. ⟨hal-02142832⟩
    • M. Garbacz, G. Battistoni, M. Durante, J. Gajewski, Nils Krah, et al.. Proton Therapy Treatment Plan Verification in CCB Krakow Using Fred Monte Carlo TPS Tool. World Congress on Medical Physics and Biomedical Engineering 2018, pp.783-787, 2019, 978-981-10-9035-6. ⟨10.1007/978-981-10-9035-6_144⟩. ⟨hal-02056752⟩
    • Pascaline Delalande, Philippe Lalle, Luc Massou, Carole Nocera-Picand, Nathalie Younes. Quels usages d’un dispositif de formation continue en ligne Ă  la pĂ©dagogie universitaire ? Le cas du MOOC « Se former pour enseigner dans le supĂ©rieur ». Distances et MĂ©diations des Savoirs, 2019, 26, pp.[En ligne]. ⟨10.4000/dms.3532⟩. ⟨halshs-03085395⟩
    • E. Armengaud, C. Augier, A.S. Barabash, F. Bellini, A. Benoit, et al.. Precise measurement of 2ν2\beta decay of ^{100}Mo with Li_2MoO_4 low temperature detectors: Preliminary results. Matrix Elements for the Double-beta-decay EXperiments, May 2019, Prague, Czech Republic. pp.020005, ⟨10.1063/1.5130966⟩. ⟨hal-02394748⟩

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