Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
546 documents

  • Djamel Dabli, Gerard Montarou, M. Beuve, C. Rodriguez-Lafrasse. RBE Modelization: Present Status and Future Prospects. 2nd NIRS-ETOILE Joint Symposium on Carbon Ion Therapy, Nov 2011, Lyon, France. ⟨in2p3-00773051⟩
  • M. Beuve, M.-A. Chanrion, U. Jelen, A. Wittig, K. Zink, et al.. The Need of Clinical Endpoint to feed RBE Models. 2nd NIRS-ETOILE Joint Symposium on Carbon Ion Therapy, Nov 2011, Lyon, France. ⟨in2p3-00773048⟩
  • M. Beuve. O2 and glutathione effects on water radiolysis: a simulation study. Nano-IBCT (Nano-scale insights into Ion Beam Cancer Therapy) 2011: Radiation damage of biomolecular systems, Oct 2011, Caen, France. ⟨in2p3-00772876⟩
  • G. Bertrand, M. Maalouf, P. Battiston-Montagne, M. Beuve, Clarisse Fournier, et al.. Ciblage des cellules souches cancéreuses, une étape essentielle pour augmenter l'efficacité de la radiothérapie dans les cancers épidermoÏdes de la tête et du cou. 10th CIRFA, Sep 2011, Anglet, France. ⟨in2p3-00773091⟩
  • G. Alphonse, M. Hanot, A. Boivin, G. Bertrand, M. Maalouf, et al.. Targeting the Main Causes of Reccurrence in Head and Neck Squamous Cell Carcinoma to Overcome Resistance to Carbon Ion Radiation. 14th International Congress of Radiation Research, Aug 2011, Varsovie, Poland. ⟨in2p3-00777418⟩
  • Pierre Henriquet. Etude de l'émission de particules chargées secondaires dans l'optique d'un monitorage faisceau et de la dosimétrie en ligne en hadronthérapie. Physique Médicale [physics.med-ph]. Université Claude Bernard - Lyon I, 2011. Français. ⟨NNT : ⟩. ⟨tel-00712778⟩
  • E. Testa, M. Bajard, M. Chevallier, D. Dauvergne, G. Dedes, et al.. Interaction vertex imaging (IVI): a new method of real-time control imaging for carbon ion therapy. PTCOG 50, May 2011, Philadelphie, United States. ⟨in2p3-00772822⟩
  • E. Testa, M. Beuve, L. Chollier, D. Dauvergne, Djamel Dabli, et al.. Modélisation de la Dose Biologique: enjeux et défis. ETOILE-MELUSYN, Feb 2011, Lyon, France. ⟨in2p3-00772783⟩
  • Djamel Dabli, Gerard Montarou, M. Beuve, C. Rodriguez-Lafrasse. RBE modelization: Present Status and Future Prospects. 2011, 22 p. ⟨in2p3-00659263⟩
  • D. Dauvergne, M. Chevallier, N. Freud, J.-M. Létang, Gerard Montarou, et al.. Novel imaging systems for online control of ion therapy. Bulletin du Cancer, 2011, 98, pp.S101-S101. ⟨in2p3-00702752⟩

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