Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
476 documents

  • U. Milkau, E. Berdermann, B. Berthier, P. Bouissou, C. Cerruti, et al.. Intermediate mass fragments from ^{40}Ar+^{197}Au:transition from the incomplete fusion to the participant spectator regime. Physical Review C, 1991, 44, pp.R1242-R1245. ⟨in2p3-00014640⟩
  • P.F. Box, T.M.V. Bootsma, C. Twenhoefel, P. Decowski, G.J. Van Nieuwenhuizen, et al.. Complex fragment emission in ^{28}Si + ^{nat}Si. Spring Meeting on Nuclear Physics Sections of the DPG, Mar 1990, Strasbourg, France. pp.1404-(A2.2). ⟨in2p3-00007227⟩
  • P. Decowski, F. Altena, P.F. Box, E. Gierlik, K.A. Griffioen, et al.. Saturation effects in the fusion of ^{28}Si nuclei at bombarding energies between 20 and 35 MeV/nucleon. International Winter Meeting On Nuclear Physics 28, Jan 1990, Bormio, Italy. pp.368-380. ⟨in2p3-00013364⟩
  • K.A. Griffioen, R.J. Meijer, P.F. Box, P. Decowski, G.J. van Nieuwenhuizen, et al.. Limiting excitation energy in the reaction Si + Si. Physics Letters B, 1990, 237, pp.24-28. ⟨10.1016/0370-2693(90)90454-E⟩. ⟨in2p3-00013253⟩
  • N. Redon, J. Meyer, M. Meyer, P. Quentin. Approximate energy correction for particle number symmetry breaking in constrained Hartree-Fock plus BCS calculations. Physical Review C, 1990, 41, pp.341-349. ⟨in2p3-00007524⟩
  • J. Aeysto, P.P. Jauho, Z. Janas, A. Jokinen, J.M. Parmonen, et al.. Collective structure of the neutron-rich nuclei,^{110}Ru and ^{112}Ru. Nuclear Physics A, 1990, 515, pp.365-380. ⟨in2p3-00007525⟩
  • P. Decowski, P. Box, K.A. Griffioen, E. Gierlik, R. Kamermans, et al.. Heavy ion interactions at fermi velocity. Zakopane School on Physics, Apr 1989, Zakopane, Poland. pp.110-128. ⟨in2p3-00013363⟩
  • R.J. Meijer, P. Box, P. Decowski, K.A. Griffioen, R. Kamermans, et al.. Central collisions between ^{28}Si nuclei at 12.4 19.7 and 30.0 MeV per nucleon. International Winter Meeting on Nuclear Physics 27, Jan 1989, Bormio, Italy. pp.203-219. ⟨in2p3-00004622⟩
  • P.F. Box, P. Decowski, K.A. Griffioen, R. Kamermans, R.J. Meijer, et al.. Evolution of the ^{28}Si + ^{(nat)}Si reaction mechanisms in the energy range 8-30 MeV/nucleon. Spring Meeting Of Nuclear Physics Sections, Mar 1988, Berlin, Germany. pp.120. ⟨in2p3-00013353⟩
  • R. Béraud, A. Charvet, R. Duffait, A. Emsallem, J. Genevey, et al.. Identification and structure of p-rich rare-earth nuclei investigated using a He-jet fed on-line mass-separator. International Conference On Nuclei Far From Stability 5, Sep 1987, Lake Rosseau, Canada. pp.445-454. ⟨in2p3-00004683⟩

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