Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • G. Drobychev, A. Barysevich, K. Delendik, P. Nédélec, D. Sillou, et al.. Advances in anodic alumina MCP development. 5th International Conference on New Developments In Photodetection 2008 (NDIP08), Jun 2008, Aix-les-Bains, France. pp.246-248, ⟨10.1016/j.nima.2009.05.076⟩. ⟨in2p3-00447166⟩
  • R. Barbier, J. Baudot, E. Chabanat, P. Depasse, W. Dulinski, et al.. Performance study of a MegaPixel single photon position sensitive photodetector EBCMOS. 5th International Conference on New Developments In Photodetection 2008, Jun 2008, Aix-les-Bains, France. ⟨in2p3-00407678⟩
  • M. Alexander, B.C. Allanach, A.J. Barr, K. Benakli, F. Boudjema, et al.. Physics beyond the standard model: supersymmetry. Workshop "Physics at TeV colliders", Jun 2008, Les Houches, France. pp.291-361. ⟨in2p3-00308757⟩
  • X. Derkx, F. Rejmund, M. Caamano, G. Barreau, B. Jurado, et al.. Isotopic production rate in minor actinide fission. EURORIB'08, Jun 2008, Giens, France. ⟨in2p3-00346288⟩
  • A. Maj, F. Azaiez, D. Balabanski, P. Bednarczyk, D. Chakrabarty, et al.. PARIS: a novel gamma calorimeter. EURORIB'08, Jun 2008, Giens, France. ⟨in2p3-00345379⟩
  • E. Schibler, J.-C. Ianigro, A. Bonnevaux, T. André, D. Guinet, et al.. Design of the Faraday cups and the beam dumps for SPIRAL 2. EURORIB'08, Jun 2008, Giens, France. ⟨in2p3-00345470⟩
  • F. Prino, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. J / ψ azimuthal anisotropy relative to the reaction plane in Pb-Pb collisions at 158 GeV per nucleon. 3rd International Conference On Hard And Electromagnetic Probes Of High-Energy Nuclear Collisions (HP2008), Jun 2008, Illa da Toxa, Spain. pp.853-858, ⟨10.1140/epjc/s10052-009-0907-4⟩. ⟨in2p3-00382161⟩
  • S. Della-Negra, J. Depaw, M. Pautrat, G. Rizza, A. Dunlop, et al.. Massive Cluster Impact : Mechanisms and future Development. DESORPTION 2008, Innovations in mass spectrometry of biomolecules, Jun 2008, Kenora, Canada. ⟨in2p3-00464862⟩
  • R. Arnaldi, K. Banicz, K. Borer, J. Castor, B. Chaurand, et al.. NA60 results on thermal dimuons. Electromagnetic Probes of High-Energy Nuclear Collisions, Hard Probes 2008, Jun 2008, Illa da toxa, Spain. pp.711-720, ⟨10.1140/epjc/s10052-009-0878-5⟩. ⟨in2p3-00373113⟩
  • R. Arnaldi, K. Banicz, K. Borer, J. Castor, B. Chaurand, et al.. NA60 results on quarkonia. 3nd International Conference on Hard andc Electromagnetic Probes of High-Energy Nuclear Collisions, Hard Probes 2008, Jun 2008, Illa da Toxa, Spain. ⟨in2p3-00373117⟩

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