Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- S. Bailey, G. Aldering, P. Antilogus, C. Aragon, C. Baltay, et al.. Initial Hubble Diagram Results from the Nearby Supernova Factory. 34th International Conference on High Energy Physics - ICHEP08, Jul 2008, Philadelphia, United States. ⟨in2p3-00347476⟩
- Y. Pipon, C. Raepsaet, D. Roudil, H. Khodj. The use of NRA to study thermal diffusion of helium in (U,Pu)O-2. 11th International Conference on Nuclear Microprobe Technology and Applications/3rd International Workshop on Proton Beam Writing, Jul 2008, Debrecen, Hungary. pp.2250-2254, ⟨10.1016/j.nimb.2009.03.025⟩. ⟨in2p3-00409563⟩
- Khalid Samraoui. Simulation de la dissociation d'agrégats d'hydrogène
Hn+ (5 ≤ n ≤ 39) induite par collision avec un atome d'hĂ©lium Ă haute vitesse (V > VBohr).. Physique [physics]. FacultĂ© des Sciences Ben M'sick de Casablanca, 2008. Français. ⟨NNT : ⟩. ⟨tel-00392739v2⟩ - Y. Copin, G. Aldering, P. Antilogus, C. Aragon, S. Bailey, et al.. The Nearby Supernova Factory: First Results. Dark Energy and Dark Matter: Observations, Experiments and Theories - CRAL-IPNL Conference, Jul 2008, Lyon, France. pp.11-15, ⟨10.1051/eas/0936002⟩. ⟨in2p3-00408916⟩
- VĂ©ronique Sanglard. Status of the EDELWEISS-II experiment. Dark Energy and Dark Matter: Observations, Experiments and Theories, Jul 2008, Lyon, France. pp.237-242, ⟨10.1051/eas/0936033⟩. ⟨hal-00353101⟩
- Y. Copin. The Nearby Supernova Factory. Semaine de l'Astrophysique Française - JournĂ©es de la SF2A 2008, Jun 2008, Paris, France. ⟨in2p3-00325076⟩
- O. Stézowski, D. Guinet, Ph. Lautesse, M. Meyer, N. Redon, et al..
-ray Spectroscopy of Proton Drip-Line Nuclei in the A~130 Region using SPIRAL beams. Nuclear Physics and Astrophysics: From Stable Beams to Exotic Nuclei, Jun 2008, Cappadocia, Turkey. pp.166-171, ⟨10.1063/1.3039823⟩. ⟨in2p3-00358543⟩ - C. Cerna, M. H. Aumeunier, E. Prieto, A. Ealet, P. Karst, et al.. Setup and Performances of the SNAP Spectrograph Demonstrator. SPIE Conference Space Telescopes and Instrumentation 2008: Optical, Infrared, and Millimeter, Jun 2008, Marseille, France. pp.70101A, ⟨10.1117/12.789583⟩. ⟨in2p3-00467942⟩
- E. Bechetoille, H. Mathez. CMOS Charge amplifier for liquid argon Time Projection Chamber detectors. WOLTE 8, Workshop On Low Temperature Electronics, Jun 2008, Jena, Germany. ⟨in2p3-00339737v2⟩
- O. Stézowski. La spectroscopie
: des faisceaux stables aux faisceaux radioactifs. Physique NuclĂ©aire ThĂ©orique [nucl-th]. UniversitĂ© Claude Bernard - Lyon I, 2008. ⟨tel-00406394⟩
Powered by HAL 