Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • H. Kraus, E. Armengaud, M. Bauer, I. Bavykina, A. Benoit, et al.. EURECA – setting the scene for scintillators. 1st International Workshop on Radiopure Scintillators for EURECA (RPScint 2008), Sep 2008, Kiev, Ukraine. pp.7-11. ⟨in2p3-01353375⟩
  • Virginie Wasselin-Trupin, Claire Guipponi, Nathalie Millard-Pinard, Eric Serris, Michèle Pijolat, et al.. Researches in safety of compacted waste and spent nuclear fuel. 12th International High-level Radioactive Waste Management Conference (IHLRWM 2008), Sep 2008, Las Vegas, United States. pp.367-371. ⟨emse-00590337⟩
  • A. Variola, J.P. Brasile, C. Bruni, R. Chehab, R. Chiche, et al.. The LAL compton program. Compton sources for X/γ rays: Physics and applications, Sep 2008, Alghero, Italy. pp.S83-S86, ⟨10.1016/j.nima.2009.05.029⟩. ⟨in2p3-00385578⟩
  • D. Autiero, I. Efthymiopoulos, Anthony Ferrari, E. Gschwendtner, A. Guglielmi, et al.. The CNGS neutrino beam: status. Neutrino Oscillation Workshop - NOW 2008, Sep 2008, Conca Specchiulla, Oranto, Italy. pp.188-190, ⟨10.1016/j.nuclphysbps.2009.02.047⟩. ⟨in2p3-00372131⟩
  • O. Albouy. Matrix reduction and Lagrangian submodules. 2008. ⟨in2p3-00319021⟩
  • M. Beuve, Djamel Dabli, Z. Francis, Gerard Montarou. Calculation of the physical proximity function t(x) for electrons, protons and carbon ions using Geant4.. 36th annual meeting of the European Radiation Research Society (ERR 2008), Sep 2008, Tours, France. ⟨10.1051/radiopro:2008661⟩. ⟨in2p3-00337141⟩
  • A. Maj, F. Azaiez, D. Jenkins, Ch. Schmitt, O. Stezowski, et al.. The PARIS project. Zakopane Conference on Nuclear Physics, Sep 2008, Zakopane, Poland. pp.565-575. ⟨in2p3-00371731⟩
  • J. Baudot, W. Dulinski, M. Winter, R. Barbier, E. Chabanat, et al.. Photon detection with CMOS sensors for fast imaging. 8th International Conference on Position Sensitive Detectors, Sep 2008, Glasgow, United Kingdom. pp.111-114, ⟨10.1016/j.nima.2009.01.066⟩. ⟨in2p3-00405323⟩
  • Michael Beuve, C. Rodriguez-Lafrasse. In Response to Scholz et al.. International Journal of Radiation Oncology, Biology, Physics, 2008, 72 (1), pp.303. ⟨hal-00994308⟩
  • Q.T. Doan, D. Curien, O. Stezowski, J. Dudek, K. Mazurek, et al.. Search for Fingerprints of Tetrahedral Symmetry in ^{156}Gd. Zakopane Conference on Nuclear Physics, Sep 2008, Zakopane, Poland. pp.725-730. ⟨in2p3-00337788v3⟩

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