Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Eric Chabert. Intégration d'un bouchon du trajectographe au silicium de l'expérience CMS au LHC et étude du potentiel de découverte de résonances se désintégrant en paires de quarks top. Physique des Hautes Energies - Expérience [hep-ex]. Université Claude Bernard - Lyon I, 2008. Français. ⟨NNT : ⟩. ⟨tel-00363904⟩
  • A. Kendl, K. Becker, S. Denifl, O. Echt, N. Endstrasser, et al.. Hydrocarbon Characteristics in Fusion Edge Plasmas from Electron- Molecule and Ion- Surface Collision Experiments. IAEA Fusion Energy Conference, Oct 2008, Genève, Switzerland. ⟨in2p3-00401932⟩
  • A. de Falco, R. Arnaldi, K. Banicz, K. Borer, J. Castor, et al.. Highlights from NA60. Strangeness in Quark Matter 2008 conference (SQM08), Oct 2008, Beijing, China. pp.064003, ⟨10.1088/0954-3899/36/6/064003⟩. ⟨in2p3-00377479⟩
  • M. Farizon. From swift H3+ ions to collision induced fragmentation of molecular nanosystems. 70 anos do Prof. Nelson V. de Castro Faria e 10 anos do Laboratório de Colisões Atômicas e Moleculares - LaCAM, UFRJ, Oct 2008, Rio de Janeiro, Brazil. ⟨in2p3-00401805⟩
  • Thomas Lesinski. Microscopic and Beyond-Mean-Field Constraints for a New Generation of Nuclear Energy Density Functionals. Nuclear Theory [nucl-th]. Université Claude Bernard - Lyon I, 2008. English. ⟨NNT : ⟩. ⟨tel-00413766v2⟩
  • J.P. Wieleczko, Eric Bonnet, J. Gomez del Campo, M. La Commara, J.D. Frankland, et al.. Influence of the N/Z ratio on Disintegration Modes of Compound Nuclei. FUSION08: New Aspects of Heavy Ion Collisions Near the Coulomb Barrier, Sep 2008, Chicago, United States. pp.64-69, ⟨10.1063/1.3108862⟩. ⟨in2p3-00375772⟩
  • D. Autiero, I. Efthymiopoulos, Anthony Ferrari, E. Gschwendtner, A. Guglielmi, et al.. CNGS neutrino beam for long base-line experiments: present status and perspectives. Tenth International Workshop on Tau Lepton Physics, Sep 2008, Novosibirsk, Russia. pp.263-270, ⟨10.1016/j.nuclphysbps.2009.03.044⟩. ⟨in2p3-00409574⟩
  • F. Palorini. Etudes sur la matrice de mélange leptonique et sur la matière noire. High Energy Physics - Experiment [hep-ex]. Université Claude Bernard - Lyon I, 2008. English. ⟨NNT : ⟩. ⟨tel-00413522⟩
  • E. de Filippo, F. Amorini, A. Anzalone, L. Auditore, V. Baran, et al.. Dynamical Signals in Fragmentation Reactions: Time Scale Determination from Three Fragments Correlations by Using the 4\pi CHIMERA Multidetector. The IV Workshop on Particle Correlations and Femtoscopy, Sep 2008, Krakow, Poland. pp.1199-1207. ⟨in2p3-00384563⟩
  • Sacha Davidson. CP violating phases in mu-e conversion. 2008. ⟨in2p3-00319841⟩

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