Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Bernd Grambow, J. Fachinger, Catherine Landesman, N. Toulhoat, N. Moncoffre, et al.. CARBONWASTE WP6 Disposal Behaviour of i-graphite and other Carbonaceous Waste. 7th EPRI International Decommissioning and Radioactive Waste Workshop, Oct 2008, Lyon, France. ⟨in2p3-00420040⟩
  • L. Bois, F. Chassagneux, S. Parola, F. Bessueille, Y. Battie, et al.. Silver nanoparticles in a mesostructured silica film. Transalp'nano, Oct 2008, France. ⟨ujm-00327580⟩
  • E. Calvié, B. Canut, D. Albertini, J. Grégoire, M. Fallavier, et al.. Nanostructuration of surfaces with swift gold clusters. 1st Transalp'Nano 2008 Conference, Oct 2008, Lyon, France. ⟨in2p3-00589599⟩
  • X. Artru, C. Ray. Particle Acceleration in a Helical Wave Guide. Charged and Neutral Particles Channeling Phenomena - Channeling 2008, Oct 2008, Erice, Italy. ⟨in2p3-00367222⟩
  • J. Marteau. Procédé de synchronisation temporelle. Equipements principal et secondaire pour la mise en œuvre de ce procédé, procédé de fonctionnement de ces équipements principal et secondaire. France, Patent n° : 08 55227. 2008. ⟨in2p3-00417466⟩
  • R. Gaglione, H. Mathez. DIRAC: A DIgital Readout Asic for hAdronic Calorimeter. 2008 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (2008 NSS/MIC), Oct 2008, Dresden, Germany. pp.1815-1819, ⟨10.1109/NSSMIC.2008.4774745⟩. ⟨in2p3-00415913⟩
  • R. Barbier, J. Baudot, E. Chabanat, P. Depasse, W. Dulinski, et al.. New Megapixel Single Photon Position Sensitive HPD: Electron-Bombarded CMOS. IV Photon Detectors and Radiation Imaging Detectors, Oct 2008, Dresden, Germany. ⟨in2p3-00407704⟩
  • M. Otani, A. Minamino, K. Nitta, A. Ichikawa, N. Nagai, et al.. Design and construction of INGRID neutrino beam monitor for T2K neutrino experiment. 2008 IEEE Nuclear Science Symposium and Medical Imaging Conference and 16th International Workshop on Room-Temperature Semiconductor X-Ray and Gamma-Ray Detectors (NSS/MIC 2008 / RTSD 2008), Oct 2008, Dresden, Germany. pp.2930-2933, ⟨10.1109/NSSMIC.2008.4774979⟩. ⟨in2p3-01226287⟩
  • D. Autiero, I. Efthymiopoulos, Anthony Ferrari, E. Gschwendtner, A. Guglielmi, et al.. CNGS — a high-intensity neutrino facility startup issues and 2008 operational summary. 2008 IEEE Nuclear Science Symposium and Medical Imaging Conference and 16th International Workshop on Room-Temperature Semiconductor X-Ray and Gamma-Ray Detectors (NSS/MIC 2008 / RTSD 2008), Oct 2008, Dresden, Germany. pp.3081-3085, ⟨10.1109/NSSMIC.2008.4775007⟩. ⟨in2p3-01220325⟩
  • A. Bergnoli, A. Bertolin, R. Brugnera, E. Carrara, A. Cazes, et al.. The OPERA spectrometers. 2008 IEEE Nuclear Science Symposium and Medical Imaging Conference and 16th International Workshop on Room-Temperature Semiconductor X-Ray and Gamma-Ray Detectors (NSS/MIC 2008 / RTSD 2008), Oct 2008, Dresden, Germany. pp.2816-2818, ⟨10.1109/NSSMIC.2008.4774957⟩. ⟨in2p3-01226257⟩

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