Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for resonant diphoton production with the D0 detector. Physical Review Letters, 2009, 102, pp.231801. ⟨10.1103/PhysRevLett.102.231801⟩. ⟨in2p3-00353224⟩
  • Charbel Koumeir. Etude de la pulvérisation ionique de surface d'un cristal de germanium sous impact d'ions lourds rapides en condition de canalisation. Physique Atomique [physics.atom-ph]. Université Claude Bernard - Lyon I, 2008. Français. ⟨NNT : ⟩. ⟨tel-00407822⟩
  • Y. Battie, N. Destouches, A. Boukenter, A. Tishchenko, L. Bois, et al.. Etude des mécanismes de croissance optique de nanoparticules d'argent dans des films de silice mésostructurés. Journée Sol-Gel Rhône-Alpes, Dec 2008, France. ⟨ujm-00348575⟩
  • C. Guipponi, N. Millard-Pinard, N. Bérerd, E. Serris, M. Pijolat, et al.. Comparison of wet air and water radiolysis effects on oxidized Zircaloy corrosion. MRS Fall Meeting - Scientific Basis for Nuclear Waste Management XXXII, Dec 2008, Boston, United States. pp.1124-Q09-07. ⟨in2p3-00408548⟩
  • J. Tabet, S. Eden, S. Feil, G. Bruny, C. Montaño, et al.. Absolute cross sections for electron capture by swift protons (80 keV) in collision with nucleobases uracil, thymine, cytosine and adenine. Ecole de physique du CNRS « Mécanismes Moléculaires Fondamentaux en biologie », Dec 2008, Biarritz, France. ⟨in2p3-00401836⟩
  • M. Kibler. Bases for Spin Systems and Qubits. TIM-08 - Dedicated to the 60th Anniversary of Physics in the West University of Timisoara, Nov 2008, Timisoara, Romania. pp.3-10, ⟨10.1063/1.3153451⟩. ⟨in2p3-00414593⟩
  • M.-C. Ricol. Contribution à l'étude des processus nucléaires intervenant en hadronthérapie et de leur impact sur la délocalisation du dépôt de dose. Physique Nucléaire Théorique [nucl-th]. Université Claude Bernard - Lyon I, 2008. Français. ⟨NNT : ⟩. ⟨tel-00413280⟩
  • R. Arnaldi, K. Banicz, J. Castor, B. Chaurand, C. Cicalò, et al.. Thermal Dimuon Emission in In-In at the CERN SPS. 2008. ⟨in2p3-00342023⟩
  • H. Abdoul-Carime, Bernadette Farizon, Michel Farizon, Eugen Illenberger. Damage to Protein and its Building-blocks induced by Electrons at Sub-excitation Energies. ESF Research Conference on Chemical Control with Electrons and Photons, Nov 2008, Obergurlg, Austria. ⟨in2p3-00401807⟩
  • D. Mercier. Bimodalité en collisions périphériques et centrales : systématiques et comparaisons. Physique Nucléaire Théorique [nucl-th]. Université de Caen, 2008. Français. ⟨NNT : ⟩. ⟨tel-00354154⟩

Powered by HAL logo