Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Rafic Faddoul, Wassim Raphael, A. Chateauneuf, Abdul-Hamid Soubra. Optimal planning of inspection and maintenance by including epistemic Uncertainties. First International Conference on Soft Computing Technology in Civil, Structural And Environmental Engineering, 2009, Funchal (Madeira Island), Portugal. ⟨hal-01008621⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Determination of the strong coupling constant from the inclusive jet cross section in ppbar collisions at sqrt(s)=1.96 TeV. Physical Review D, 2009, 80, 111107(r) 7 p. ⟨10.1103/PhysRevD.80.111107⟩. ⟨in2p3-00432701⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of the semileptonic branching ratio of B0_s to an orbitally excited D_s** state, Br(B0_s -> Ds1(2536) mu nu). Physical Review Letters, 2009, 102, pp.051801. ⟨10.1103/PhysRevLett.102.051801⟩. ⟨in2p3-00201673⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of the ttbar production cross section and top quark mass extraction using dilepton events in ppbar collisions. Physics Letters B, 2009, 679, pp.177-185. ⟨10.1016/j.physletb.2009.07.032⟩. ⟨in2p3-00354532⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Relative rates of B meson decays into psi(2S) and J/psi mesons. Physical Review D, 2009, 79, pp.111102. ⟨10.1103/PhysRevD.79.111102⟩. ⟨in2p3-00280494⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Combination of ttbar cross section measurements and constraints on the mass of the top quark and its decays into the charged Higgs bosons. Physical Review D, 2009, 80, pp.071102(R). ⟨10.1103/PhysRevD.80.071102⟩. ⟨in2p3-00372843⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for Next-to-Minimal Supersymmetric Higgs Bosons in the h->aa->mumu mumu, mumu tautau channels using ppbar collisions at sqrt{s}=1.96 TeV. Physical Review Letters, 2009, 103, pp.061801. ⟨10.1103/PhysRevLett.103.061801⟩. ⟨in2p3-00388095⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for Resonant Pair Production of neutral long-lived particles decaying to bbbar in ppbar collisions at sqrt(s)=1.96 TeV. Physical Review Letters, 2009, 103, pp.071801. ⟨10.1103/PhysRevLett.103.071801⟩. ⟨in2p3-00393875⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for long-lived charged massive particles with the D0 detector. Physical Review Letters, 2009, 102, pp.161802. ⟨10.1103/PhysRevLett.102.161802⟩. ⟨in2p3-00325046⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Evidence for the decay B_s^0 --> D_s^(*)D_s^(*) and a measurement of Delta_Gamma_s^CP/Gamma_s. Physical Review Letters, 2009, 102, pp.091801. ⟨10.1103/PhysRevLett.102.091801⟩. ⟨in2p3-00338690⟩

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