Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Relative rates of B meson decays into psi(2S) and J/psi mesons. Physical Review D, 2009, 79, pp.111102. ⟨10.1103/PhysRevD.79.111102⟩. ⟨in2p3-00280494⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Combination of ttbar cross section measurements and constraints on the mass of the top quark and its decays into the charged Higgs bosons. Physical Review D, 2009, 80, pp.071102(R). ⟨10.1103/PhysRevD.80.071102⟩. ⟨in2p3-00372843⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for Resonant Pair Production of neutral long-lived particles decaying to bbbar in ppbar collisions at sqrt(s)=1.96 TeV. Physical Review Letters, 2009, 103, pp.071801. ⟨10.1103/PhysRevLett.103.071801⟩. ⟨in2p3-00393875⟩
  • M. Martini, G. Chanfray, M. Ericson, J. Marteau. Neutrino interactions with nuclei. 6th International Workshop on Neutrino-Nucleus Interactions in the Few-GeV Region (NuInt09), 2009, Sitges, Spain. ⟨10.1063/1.3274176⟩. ⟨in2p3-00413202⟩
  • P. Costa, M.C. Ruivo, C. A. de Sousa, H. Hansen, W. M. Alberico. Scalar-pseudoscalar meson behavior and restoration of symmetries in SU(3) PNJL model. Physical Review D, 2009, 79, pp.116003. ⟨10.1103/PhysRevD.79.116003⟩. ⟨in2p3-00409560⟩
  • A. Bandyopadhyay, S. Choubey, R. Gandhi, S. Goswami, B.L. Roberts, et al.. Physics at a future Neutrino Factory and super-beam facility. Reports on Progress in Physics, 2009, 72, pp.106201. ⟨10.1088/0034-4885/72/10/106201⟩. ⟨in2p3-00423008⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of the W boson mass. Physical Review Letters, 2009, 103, pp.141801. ⟨10.1103/PhysRevLett.103.141801⟩. ⟨in2p3-00409687⟩
  • M. Testa, M. Bajard, M. Chevallier, D. Dauvergne, N. Freud, et al.. A novel technique for real time monitoring of the Bragg-peak position in ion therapy by means of single photon detection. Heavy Ions in Therapy and Space Symposium, 2009, Unknown, Unknown Region. ⟨hal-01920986⟩
  • K. Bennaceur. New terms and new constrains for the Skyrme Energy Density Functional. Arctic FIDIPRO-EFES Workshop, 2009, Saariselka, Finland. ⟨in2p3-00973401⟩
  • V. Rotival, K. Bennaceur, T. Duguet. Halo phenomenon in finite many-fermion systems: Atom-positron complexes and large-scale study of atomic nuclei. Physical Review C, 2009, 79, pp.054309. ⟨10.1103/PhysRevC.79.054309⟩. ⟨in2p3-00186434⟩

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