Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
546 documents

  • G. Bertrand, M. Maalouf, A. Boivin, P. Battiston-Montagne, M. Beuve, et al.. Molecular mechanism of tumor cell radioresistance in head and neck squamous cell carcinos. 7èmes Journées Scientifiques du Cancéropôle CLARA, Mar 2012, Lyon, France. ⟨hal-00839205⟩
  • F. Roellinghoff, A. Benilov, D. Dauvergne, G. Dedes, N. Freud, et al.. 235 Real-time proton beam range monitoring by means of prompt-gamma detection with a collimated camera. ICTR-PHE 2012, Feb 2012, Genève, Switzerland. pp.S120-S121, ⟨10.1016/S0167-8140(12)70203-7⟩. ⟨hal-01118500⟩
  • E. Testa, M. Chevallier, D. Dauvergne, G. Dedes, M. de Rydt, et al.. Real-time monitoring of the Bragg peak during ion therapy:a feasibility study of interaction vertex imaging. ICTR-PHE 2012 Conference, Feb 2012, Genève, Switzerland. pp.S123, ⟨10.1016/S0167-8140(12)70208-6⟩. ⟨hal-00990839⟩
  • G. Dedes, M. Chevallier, D. Dauvergne, M. de Rydt, N. Freud, et al.. Real-time prompt gamma ray monitoring for proton and carbon therapy:Monte Carlo nuclear models evaluation and improvements. ICTR-PHE 2012 Conference, Feb 2012, Genève, Switzerland. pp.S68-S69, ⟨10.1016/S0167-8140(12)70120-2⟩. ⟨hal-00990819⟩
  • M. de Rydt, M. Chevallier, D. Dauvergne, S. Deng, G. Dedes, et al.. Real-time monitoring of the Bragg peak during ion therapy:recent developements of the beam detection system. ICTR-PHE 2012 Conference, Feb 2012, Genève, Switzerland. pp.S60-S61, ⟨10.1016/S0167-8140(12)70108-1⟩. ⟨hal-00990830⟩
  • E. Testa, M. Chevallier, D. Dauvergne, G. Dedes, M. de Rydt, et al.. Spatial correlations between images derived from dynamic FDG-PET. ICTR-PHE 2012 Conference, Feb 2012, Genève, Switzerland. pp.S122-S123, ⟨10.1016/S0167-8140(12)70207-4⟩. ⟨hal-00990834⟩
  • Jacques Saadé, Hamid Ladjal, Shariat Behzad, M. Beuve, Joseph Azencot. Modélisation biomécanique du diaphragme humain : du CT-4D au modèle du mouvement. RFIA 2012 (Reconnaissance des Formes et Intelligence Artificielle), Jan 2012, Lyon, France. pp.978-2-9539515-2-3. ⟨hal-00656533⟩
  • Maïté Hanot, Anthony Boivin, Céline Malésys, M. Beuve, A. Colliaux, et al.. Glutathione depletion and carbon ion radiation potentiate clustered DNA lesions, cell death and prevent chromosomal changes in cancer cells progeny.. PLoS ONE, 2012, 7 (11), pp.e44367. ⟨10.1371/journal.pone.0044367⟩. ⟨hal-00788074⟩
  • M. Beuve. Methods for Radiobiological Data Acquisition, Processing, Analysis and Modelling. 1st International Workshop: Hadrontherapy in France, Nov 2011, Lyon, France. ⟨in2p3-00773078⟩
  • Djamel Dabli, Gerard Montarou, M. Beuve, C. Rodriguez-Lafrasse. RBE Modelization: Present Status and Future Prospects. 2nd NIRS-ETOILE Joint Symposium on Carbon Ion Therapy, Nov 2011, Lyon, France. ⟨in2p3-00773051⟩

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