Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Direct measurement of the W Boson Width. Physical Review Letters, 2009, 103, pp.231802. ⟨10.1103/PhysRevLett.103.231802⟩. ⟨in2p3-00433852⟩
  • M.-G. Porquet, A. Astier, Ts. Venkova, A. Prévost, I. Deloncle, et al.. High-spin excitations of ^{81, 82, 83, 85}Se : Competing single-particle and collective structures around N = 50. The European physical journal. A, Hadrons and Nuclei, 2009, 39, pp.295-306. ⟨10.1140/epja/i2008-10723-2⟩. ⟨in2p3-00378429⟩
  • R. Bès, N. Millard-Pinard, S. Gavarini, Sandrine Cardinal. Migration thermique du xénon dans le nitrure de titane polycristallin. Rencontres jeunes chercheurs 2008, 2009, Les Houches, France. ⟨in2p3-01018497⟩
  • Benjamin Depardon, Eddy Caron, Frédéric Desprez, H.M. Courtois, Jeremy Blaizot. Cosmological Simulations on a Grid of Computers. [Research Report] RR-7093, Inria. 2009, pp.15. ⟨inria-00431637⟩
  • X. Artru, M. Elchikh, J.-M. Richard, J. Soffer, O.V. Teryaev. Spin observables and spin structure functions: inequalities and dynamics. Physics Reports, 2009, 470, pp.1-92. ⟨10.1016/j.physrep.2008.09.004⟩. ⟨in2p3-00238395⟩
  • M. Bajard, M. Chevallier, D. Dauvergne, F. Fle Foulher, N. Freud, et al.. Target influence on real time monitoring of the Bragg peak location by means of single photon detection. PTCOG: Particle Therapy Co-Operative Group 48, 2009, Unknown, Unknown Region. ⟨hal-01920983⟩
  • S. Gavarini, R. Bès, C. Peaucelle, P. Martin, C. Esnouf, et al.. Caesium isothermal migration behaviour in sintered titanium nitride: New data and comparison with previous results on iodine and xenon. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2009, 267, pp.1942-1947. ⟨10.1016/j.nimb.2009.03.106⟩. ⟨in2p3-00399343⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for a scalar or vector particle decaying into Zgamma in ppbar collisions at sqrt(s) = 1.96 TeV. Physics Letters B, 2009, 671, pp.349-355. ⟨10.1016/j.physletb.2008.12.009⟩. ⟨in2p3-00284900⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for anomalous top-quark couplings with the D0 detector. Physical Review Letters, 2009, 102, pp.092002. ⟨10.1103/PhysRevLett.102.092002⟩. ⟨in2p3-00349886⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for admixture of scalar top quarks in the ttbar lepton+jets final state at sqrt(s)=1.96 TeV. Physics Letters B, 2009, 674, pp.4-10. ⟨10.1016/j.physletb.2009.02.027⟩. ⟨in2p3-00351438⟩

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