Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for anomalous top-quark couplings with the D0 detector. Physical Review Letters, 2009, 102, pp.092002. ⟨10.1103/PhysRevLett.102.092002⟩. ⟨in2p3-00349886⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for admixture of scalar top quarks in the ttbar lepton+jets final state at sqrt(s)=1.96 TeV. Physics Letters B, 2009, 674, pp.4-10. ⟨10.1016/j.physletb.2009.02.027⟩. ⟨in2p3-00351438⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for Large extra spatial dimensions in the dielectron and diphoton channels in p \bar{p} collisions at \sqrt{s} = 1.96-TeV. Physical Review Letters, 2009, 102, pp.051601. ⟨10.1103/PhysRevLett.102.051601⟩. ⟨in2p3-00322600⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of sigma(ppbar -> Z + X) Br(Z -> tau+tau-) at sqrt(s)=1.96 TeV. Physics Letters B, 2009, 670, pp.292-299. ⟨10.1016/j.physletb.2008.11.010⟩. ⟨in2p3-00310961⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for pair production of second generation scalar leptoquarks. Physics Letters B, 2009, 671, pp.224-232. ⟨10.1016/j.physletb.2008.12.017⟩. ⟨in2p3-00315791⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for dark photons from supersymmetric hidden valleys. Physical Review Letters, 2009, 103, pp.081802. ⟨10.1103/PhysRevLett.103.081802⟩. ⟨in2p3-00383553⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Determination of the strong coupling constant from the inclusive jet cross section in ppbar collisions at sqrt(s)=1.96 TeV. Physical Review D, 2009, 80, 111107(r) 7 p. ⟨10.1103/PhysRevD.80.111107⟩. ⟨in2p3-00432701⟩
  • Rafic Faddoul, Wassim Raphael, A. Chateauneuf, Abdul-Hamid Soubra. Optimal planning of inspection and maintenance by including epistemic Uncertainties. First International Conference on Soft Computing Technology in Civil, Structural And Environmental Engineering, 2009, Funchal (Madeira Island), Portugal. ⟨hal-01008621⟩
  • Francisco Chinesta, A. Ma, M. R. Mackley, Elías Cueto. Nano-Composites : From Rheology to Forming Process Simulation. 17th International Conference on Composite Materials (ICCM), 2009, Edimburg, United Kingdom. ⟨hal-01008521⟩
  • T. Frisson, N. Zahra, P. Lautesse, D. Sarrut. Monte-Carlo based prediction of radiochromic film response for hadrontherapy dosimetry. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2009, 606 (3), pp.749-754. ⟨10.1016/j.nima.2009.04.027⟩. ⟨in2p3-00407993⟩

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