Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • S. Abdullin, V. Abramov, B. Acharya, N. Adam, M. Adams, et al.. ERRATUM : The CMS barrel calorimeter response to particle beams from 2 to 350 GeV/c. European Physical Journal C: Particles and Fields, 2009, 61, pp.353-356. ⟨10.1140/epjc/s10052-009-1024-0⟩. ⟨in2p3-00400337⟩
  • G. Cacciapaglia, A. Deandrea, S. de Curtis. Nearby resonances beyond the Breit-Wigner approximation. Physics Letters B, 2009, 682, pp.43-49. ⟨10.1016/j.physletb.2009.10.090⟩. ⟨in2p3-00397464⟩
  • W. Adam, T. Bergauer, M. Dragicevic, M. Friedl, R. Frühwirth, et al.. Alignment of the CMS Silicon Strip Tracker during stand-alone Commissioning. Journal of Instrumentation, 2009, 4, pp.T07001. ⟨10.1088/1748-0221/4/07/T07001⟩. ⟨in2p3-00413049⟩
  • R. Acquafredda, T. Adam, N. Agafonova, P. Alvarez Sanchez, M. Ambrosio, et al.. The OPERA experiment in the CERN to Gran Sasso neutrino beam. Journal of Instrumentation, 2009, 04, pp.P04018. ⟨10.1088/1748-0221/4/04/P04018⟩. ⟨in2p3-00388711⟩
  • G. Cacciapaglia. Physics at the TeV Colliders. Les Houches summer workshop Physics at the TeV Colliders, 2009, Chamonix, France. ⟨in2p3-01023931⟩
  • M. Martini, M. Montagna, M. Ou, O. Tillement, S. Roux, et al.. How to measure quantum yields in scattering media: Application to the quantum yield measurement of fluorescein molecules encapsulated in sub-100 nm silica particles. Journal of Applied Physics, 2009, 106 (9), ⟨10.1063/1.3248302⟩. ⟨hal-01814987⟩
  • K. Bennaceur. Skyrme functionals and halo systems. ESNT Workshop "Importance of continuum coupling for nuclei close to the drip lines", 2009, Saclay. ⟨in2p3-00973405⟩
  • M. Combescure. Block circulant matrices with circulant blocks, weil sums and mutually unbiased bases, II. The prime power case. Journal of Mathematical Physics, 2009, 50, pp.032104. ⟨10.1063/1.3078420⟩. ⟨in2p3-00184037⟩
  • X. Artru, C. Ray. Electron acceleration in a helical waveguide. VIII International Symposium on Radiation from Relativistic Electrons in Periodic Structures (RREPS-2009), 2009, Zvenigorod, pp.012031, ⟨10.1088/1742-6596/236/1/012031⟩. ⟨in2p3-00441760⟩
  • G. Cacciapaglia, A. Deandrea, S. de Curtis. Effects of nearby resonances at colliders. G. Bélanger, F. Boudjema, J.-Ph. Guillet, E. Pilon. Physics at TeV Colliders, la physique du TeV aux collisionneurs Les Houches 8-26 juin 2009, Cnrs, pp.148-152, 2009. ⟨in2p3-00722275⟩

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