Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for neutral Higgs bosons at high tan(beta) in the b(h/H/A)->btautau channel. Physical Review Letters, 2009, 102, pp.051804. ⟨10.1103/PhysRevLett.102.051804⟩. ⟨in2p3-00336423⟩
  • E. Galichet, M. F. Rivet, B. Borderie, M. Colonna, R. Bougault, et al.. Isospin diffusion in semi-peripheral ^{58}Ni+^{197}Au collisions at intermediate energies (I): Experimental results. Physical Review C, 2009, 79, pp.064614. ⟨10.1103/PhysRevC.79.064614⟩. ⟨hal-00347268⟩
  • S. Abdullin, V. Abramov, B. Acharya, N. Adam, M. Adams, et al.. The CMS Barrel Calorimeter Response to Particle Beams from 2 to 350 GeV/c. European Physical Journal C: Particles and Fields, 2009, 60, pp.359-373. ⟨10.1140/epjc/s10052-009-0959-5⟩. ⟨in2p3-00378460⟩
  • W. Adam, T. Bergauer, M. Dragicevic, M. Friedl, R. Fruhwirth, et al.. Stand-alone cosmic muon reconstruction before installation of the CMS silicon strip tracker. Journal of Instrumentation, 2009, 4, pp.P05004. ⟨10.1088/1748-0221/4/05/P05004⟩. ⟨in2p3-00407835⟩
  • I. Billard, C. Gaillard. Actinide and lanthanide speciation in imidazolium-based ionic liquids. Radiochimica Acta, 2009, 97, pp.355-359. ⟨10.1524/ract.2009.1617⟩. ⟨in2p3-00409924⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. A novel method for modeling the recoil in W boson events at hadron collider. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2009, 609, pp.250-262. ⟨10.1016/j.nima.2009.08.056⟩. ⟨in2p3-00406362⟩
  • M. Martini, M. Ericson, G. Chanfray, J. Marteau. A unified approach for nucleon knock-out, coherent and incoherent pion production in neutrino interactions with nuclei. Physical Review C, 2009, 80, pp.065501. ⟨10.1103/PhysRevC.80.065501⟩. ⟨in2p3-00424236⟩
  • Etienne Testa, M. Bajard, M. Chevallier, Denis Dauvergne, Fabrice Le Foulher, et al.. Dose profile monitoring with carbon ions by means of prompt-gamma measurements. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2009, 267, pp.993-996. ⟨10.1016/j.nimb.2009.02.031⟩. ⟨hal-00283936⟩
  • J. Abdallah, P. Abreu, W. Adam, P. Adzic, T. Albrecht, et al.. Inclusive single-particle production in two-photon collisions at LEP II with the DELPHI detector. Physics Letters B, 2009, 678, pp.444-449. ⟨10.1016/j.physletb.2009.06.058⟩. ⟨in2p3-00405210⟩
  • R. Arnaldi, K. Banicz, J. Castor, B. Chaurand, C. Cicalo, et al.. Study of the electromagnetic transition form-factors in \eta -> \mu^+\mu^-\gamma and \omega -> \mu^+\mu^-\pi^0 decays with NA60. Physics Letters B, 2009, 677, pp.260-266. ⟨10.1016/j.physletb.2009.05.029⟩. ⟨in2p3-00365406⟩

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