Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • D. Dauvergne, E. Balanzat, C. Trautmann. Swift Heavy Ions in Matter, Proceedings of the Seventh International Symposium on Swift Heavy Ions in Matter (SHIM 2008). Seventh International Symposium on Swift Heavy Ions in Matter (SHIM 2008), Jun 2008, Lyon, France. Elsevier, 2009, Nuclear Instruments and Methods in Physics Research Section B. ⟨in2p3-00408002⟩
  • A. Broniatowski, X. Defay, E. Armengaud, L. Berge, Alain Benoit, et al.. A new high-background-rejection dark matter Ge cryogenic detector. Physics Letters B, 2009, 681, pp.305-309. ⟨10.1016/j.physletb.2009.10.036⟩. ⟨in2p3-00381573⟩
  • S. Abdullin, V. Abramov, B. Acharya, N. Adam, M. Adams, et al.. ERRATUM : The CMS barrel calorimeter response to particle beams from 2 to 350 GeV/c. European Physical Journal C: Particles and Fields, 2009, 61, pp.353-356. ⟨10.1140/epjc/s10052-009-1024-0⟩. ⟨in2p3-00400337⟩
  • G. Cacciapaglia, A. Deandrea, J. Llodra-Perez. Higgs to Gamma Gamma beyond the Standard Model. Journal of High Energy Physics, 2009, 06(2009), pp.054. ⟨10.1088/1126-6708/2009/06/054⟩. ⟨in2p3-00409566⟩
  • G. Smadja, C. Cerna, A. Ealet. Measurement of the Non-Linearity and Interpixel Capacitance of a H2RG (2Kx2K) Near-IR Detector. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2009, 610, pp.615-621. ⟨10.1016/j.nima.2009.08.070⟩. ⟨in2p3-00467907⟩
  • R. Arnaldi, K. Banicz, K. Borer, J. Castor, B. Chaurand, et al.. Evidence for the production of thermal-like muon pairs with masses above 1 GeV/c^2 in 158A GeV Indium-Indium Collisions. European Physical Journal C: Particles and Fields, 2009, 59, pp.607-623. ⟨10.1140/epjc/s10052-008-0857-2⟩. ⟨in2p3-00338447⟩
  • Francisco Chinesta, Elías Cueto. Flow Induced Orientation of Fibres, Micro-Fibres and Nano-Tubes: Beyond the Jeffery's Model. International Alpine Rheology Meeting, 2009, Les Saisies, France. ⟨hal-01008231⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of the lifetime of the B^+-_c meson in the semileptonic decay channel. Physical Review Letters, 2009, 102, pp.092001. ⟨10.1103/PhysRevLett.102.092001⟩. ⟨in2p3-00280845⟩
  • M.-H. Richard, M. Chevallier, D. Dauvergne, N. Freud, P. Henriquet, et al.. Design of a Compton camera for 3D prompt-gamma imaging during ion beam therapy: a Geant4 simulation study. IEEE Nuclear Science Symposium / Medical Imaging Conference, 2009, Unknown, Unknown Region. ⟨hal-01920982⟩
  • P. Costa, C.A. de Sousa, M.C. Ruivo, H. Hansen. The QCD critical end point in the PNJL model. EPL - Europhysics Letters, 2009, 86, pp.31001. ⟨10.1209/0295-5075/86/31001⟩. ⟨in2p3-00215934⟩

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