Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of dijet angular distributions at sqrt{s}=1.96TeV and searches for quark compositeness and extra spatial dimensions. Physical Review Letters, 2009, 103, pp.191803. ⟨10.1103/PhysRevLett.103.191803⟩. ⟨in2p3-00399719⟩
- V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for squark production in events with jets, hadronically decaying tau leptons and missing transverse energy at sqrt(s)=1.96 TeV. Physics Letters B, 2009, 680, pp.24-33. ⟨10.1016/j.physletb.2009.08.002⟩. ⟨in2p3-00388678⟩
- V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Evidence of WW+WZ production with lepton + jets final states in proton-antiproton collisions at sqrt(s)=1.96 TeV. Physical Review Letters, 2009, 102, pp.161801. ⟨10.1103/PhysRevLett.102.161801⟩. ⟨in2p3-00332883⟩
- V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for associated production of charginos and neutralinos in the trilepton final state using 2.3 fb-1 of data. Physics Letters B, 2009, 680, pp.34-43. ⟨10.1016/j.physletb.2009.08.011⟩. ⟨in2p3-00350972⟩
- V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for charged Higgs bosons decaying into top and bottom quarks in ppbar collisions. Physical Review Letters, 2009, 102, pp.191802. ⟨10.1103/PhysRevLett.102.191802⟩. ⟨in2p3-00293911⟩
- V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. A search for associated W and Higgs Boson production in ppbar collisions at sqrt{s}=1.96 TeV. Physical Review Letters, 2009, 102, pp.051803. ⟨10.1103/PhysRevLett.102.051803⟩. ⟨in2p3-00311553⟩
- V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for resonant diphoton production with the D0 detector. Physical Review Letters, 2009, 102, pp.231801. ⟨10.1103/PhysRevLett.102.231801⟩. ⟨in2p3-00353224⟩
- V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for charged Higgs bosons in top quark decays. Physics Letters B, 2009, 682, pp.278-286. ⟨10.1016/j.physletb.2009.11.016⟩. ⟨in2p3-00409921⟩
- J. Taieb, G. Belier, A. Chatillon, T. Granier, A. Kelic, et al.. ELISe: a new facility for unprecedented experimental nuclear fission studies. International Journal of Modern Physics E, 2009, 18, pp.767-772. ⟨10.1142/S0218301309012859⟩. ⟨in2p3-00394149⟩
- W. Adam, T. Bergauer, M. Dragicevic, M. Friedl, R. Fruhwirth, et al.. Performance studies of the CMS Strip Tracker before installation. Journal of Instrumentation, 2009, 4, pp.P06009. ⟨10.1088/1748-0221/4/06/P06009⟩. ⟨in2p3-00407781⟩
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