Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Vianney Motte, Dominique Gosset, Thierry Sauvage, HĂ©lène Lecoq, Nicolas Pradeilles, et al.. Corrigendum to “Helium apparent diffusion coefficient and trapping mechanisms in implanted B4C boron carbide” [J. Nucl. Mater. 517 (2019) 165–174]. Journal of Nuclear Materials, 2019, 521, pp.245. ⟨10.1016/j.jnucmat.2019.05.011⟩. ⟨hal-02489067⟩
    • Christina Agapopoulou, Mario Alcocer-Avila, Konie Al Khoury, Edgar Barlerin, Giovanni Bartolini, et al. (Dir.). JRJC 2018. Book of proceedings. 2019. ⟨hal-02271401⟩
    • K. Bennaceur, J. Dobaczewski, T. Haverinen, M. Kortelainen. Regularized pseudopotential for mean-field calculations. 27th International Nuclear Physics Conference, Jul 2019, Glasgow, United Kingdom. pp.012112, ⟨10.1088/1742-6596/1643/1/012112⟩. ⟨hal-02383325⟩
    • S. Curtoni, G. Bosson, J. Bouvier, J. Collot, D. Dauvergne, et al.. Development of a diamond hodoscope for online ion range monitoring in hadrontherapy. XVth Rencontres du Vietnam International Conference on Medical Physics and School, Jul 2019, Ho_Chi_Minh, Vietnam. ⟨hal-02351915⟩
    • D.L. Helis, I.C. Bandac, A.S. Barabash, J. Billard, M. Chapellier, et al.. Neutrinoless Double-Beta Decay Searches with Enriched ^{116}\hbox {CdWO}_{{4}} Scintillating Bolometers. 18th International Workshop on Low Temperature Detectors, Jul 2019, Milano, Italy. pp.467-474, ⟨10.1007/s10909-019-02315-2⟩. ⟨hal-02564539⟩
    • A. Juillard, J. Billard, D. Chaize, J.B. Filippini, D. Misiak, et al.. Low-noise HEMTs for Coherent Elastic Neutrino Scattering and Low-Mass Dark Matter Cryogenic Semiconductor Detectors. 18th International Workshop on Low Temperature Detectors, Jul 2019, Milano, Italy. pp.798-806, ⟨10.1007/s10909-019-02269-5⟩. ⟨hal-02317279⟩
    • Albert Saporta. Phenomenological analysis of charged lepton flavour changes. Physics [physics]. UniversitĂ© de Lyon, 2019. English. ⟨NNT : 2019LYSE1110⟩. ⟨tel-02319188⟩
    • Alessandro Caratelli, Davide Ceresa, Jarne de Clercq, Geoffrey Galbit, Mykyta Haranko, et al.. OT-\muDTC, a test bench for testing CMS Outer Tracker Phase-2 module prototypes. 2019 European Physical Society Conference on High Energy Physics, Jul 2019, Ghent, Belgium. pp.170, ⟨10.22323/1.364.0170⟩. ⟨hal-03047500⟩
    • Didier Claude Contardo. Detector R&D collider experiments. 2019 European Physical Society Conference on High Energy Physics, Jul 2019, Ghent, Belgium. pp.698, ⟨10.22323/1.364.0698⟩. ⟨hal-03047504⟩
    • M. Beuve. NanOx, a new multiscale model to predict biological effects of ionizing radiation. European Network for Light Ion Hadron Therapy (ENLIGHT) annual meeting, Jul 2019, Caen, France. ⟨hal-02355745⟩

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