Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. Bedjidian, J.-C. Ianigro, R. Kieffer, I. Laktineh, N. Lumb, et al.. Glass resistive plate chambers for a semi-digital HCAL. 1st International Conference on Technology and Instrumentation in Particle Physics (TIPP09), Mar 2009, Tsukuba, Japan. pp.120-122, ⟨10.1016/j.nima.2010.02.168⟩. ⟨in2p3-00545028⟩
  • I. Laktineh. Development of a semi-digital hadronic calorimeter using GRPC. 1st International Conference on Technology and Instrumentation in Particle Physics (TIPP09), Mar 2009, Tsukuba, Japan. pp.231-233, ⟨10.1016/j.nima.2010.02.205⟩. ⟨in2p3-00545029⟩
  • M. Otani, N. Nagai, D. Orme, A. Minamino, K. Nitta, et al.. Design and construction of INGRID neutrino beam monitor for T2K neutrino experiment. 1st International Conference on Technology and Instrumentation in Particle Physics (TIPP09), Mar 2009, Tsukuba, Japan. pp.368-370, ⟨10.1016/j.nima.2010.02.251⟩. ⟨in2p3-00545032⟩
  • J. Gascon. Direct Dark Matter Searches and the EDELWEISS-II Experiment. XLIVth Rencontres de Moriond, Electroweak Interactions and Unified Theories Session, Mar 2009, La Thuile, Italy. ⟨in2p3-00397831⟩
  • A. L’hoir, Charbel Koumeir, S. Della Negra, P. Boduch, P. Roussel-Chomaz, et al.. Study of ion emission from a germanium crystal surface under impact of fast Pb ions in channeling conditions. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2009, 267 (6), pp.876-880. ⟨10.1016/j.nimb.2009.02.041⟩. ⟨hal-00257795⟩
  • N. Redon. High-resolution Gamma-ray spectroscopy at SPIRAL2. SPIRAL2 Week, Jan 2009, Caen, France. ⟨in2p3-00990093⟩
  • O. Stézowski. Status of simulations for the PARIS project. SPIRAL2 Week, Jan 2009, Caen, France. ⟨in2p3-00990091⟩
  • R. Chierici. Generators For LHC Physics. LISHEP2009-International School on High Energy Physics - Session C - Workshop on Forward Physics, Exotica and Associated Technologies at LHC, Jan 2009, Rio de Janeiro, Brazil. ⟨in2p3-00967591⟩
  • H. Abdoul-Carime, K. El-Farkh, C. Teyssier, V. Buridon, M. Harb, et al.. Event-by-event analysis technique as a tool to investigate elementary processes in plasma. 17th Symposium on Application of Plasma Physics SAPP, Jan 2009, Liptovský Ján, Slovakia. ⟨in2p3-01061804⟩
  • G. Chanfray, M. Ericson. Relativistic Chiral Theory of Nuclear Matter and QCD Constraints. 2009. ⟨in2p3-00353713⟩

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