Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • I. Efthymiopoulos, Anthony Ferrari, E. Gschwendtner, A. Pardons, L. Sarchiapone, et al.. First Year of Physics at CNGS. Particle Accelerator Conference (PAC09), May 2009, Vancouver, Canada. ⟨in2p3-00382143⟩
  • Benjamin J Blaise, Jean Giacomotto, Mohamed N Triba, Pierre Toulhoat, Martial Piotto, et al.. Metabolic profiling strategy of Caenorhabditis elegans by whole-organism nuclear magnetic resonance.. Journal of Proteome Research, 2009, 8 (5), pp.2542-50. ⟨10.1021/pr900012d⟩. ⟨hal-00425221⟩
  • Mira Maalouf, Gersende Alphonse, Anthony Colliaux, Michaël Beuve, S Trajkovic-Bodennec, et al.. Different mechanisms of cell death in radiosensitive and radioresistant p53 mutated head and neck squamous cell carcinomas exposed to carbon ions and x-rays. International Journal of Radiation Oncology, Biology, Physics, 2009, 1, 74, pp.200-209. ⟨hal-01437696⟩
  • S. Gohlke, S. Feil, B. Farizon, M. Farizon, H. Abdoul-Carime, et al.. Electron Attachment to Biomolecules. Electron Controlled Chemical Lithography (ECCL)- COST Action CM0601 - First meeting of Working Group 1 Selective bond cleavage by electron induced dissociation, May 2009, Berlin, Germany. ⟨in2p3-00401830⟩
  • M. Bajard, M. Chevallier, D. Dauvergne, F. Le Foulher, N. Freud, et al.. Monitoring the Bragg peak location by means of prompt gamma measurements. International School on Hadrontherapy «Edwin McMillan» Workshop on Hadron Beam Therapy of Cancer, Apr 2009, Sicile, Italy. ⟨in2p3-00475607⟩
  • J.-M. Richard, X. Artru, M. Elchikh, J. Soffer, O. Teryaev. Model-independent constraints on spin observables. Workshop on the Physics of Excited Nucleon (NSTAR2009), Apr 2009, Beijing, China. pp.1153-1158, ⟨10.1088/1674-1137/33/12/017⟩. ⟨in2p3-00408122⟩
  • L. Bois, F. Chassagneux, S. Parola, F. Bessueille, Y. Battie, et al.. Growth of ordered silver nanoparticles in silica film mesostructured with a triblock copolymer PEO-PPO-PEO. Journal of Solid State Chemistry, 2009, 182, pp.1700-1707. ⟨10.1016/j.jssc.2009.01.044⟩. ⟨ujm-00416406⟩
  • C. Combaret. 1m2 GRPC Acquisition System. TILC09, Apr 2009, Tsukuba, Japan. ⟨in2p3-00967640⟩
  • Zhiping P. Wang, Phuong Mai Dinh, P. -G. Reinhard, Eric Suraud, G. Bruny, et al.. Production of intense beams of mass-selected water cluster ions and theoretical study of atom-water interactions. 2009. ⟨in2p3-00372136⟩
  • H. Jung, A. de Roeck, Ziad Zj Ajaltouni, S. Albino, G. Altarelli, et al.. Proceedings of the workshop: HERA and the LHC workshop series on the implications of HERA for LHC physics. 2009. ⟨hal-00437657⟩

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