Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. Chevallier, D. Dauvergne, N. Freud, P. Henriquet, F. Le Foulher, et al.. Nouvelles méthodes d'imagerie en ligne pour le contrôle de l'irradiation en hadronthérapie. 48emes Journées Scientifiques SFPM, Jun 2009, Montauban, France. ⟨in2p3-00405310⟩
  • J. Marteau. The OPERA global readout and GPS distribution system. 11th Pisa Meeting on Advanced Detectors, May 2009, La Biodola, Italy. pp.291-293, ⟨10.1016/j.nima.2009.10.095⟩. ⟨in2p3-00392615⟩
  • P. Russotto, E. de Filippo, A. Pagano, E. Piasecki, F. Amorini, et al.. Isospin effects in projectile-like dynamical fission for 112,124Sn+58,64Ni reactions at 35 AMeV. 4th International Workshop on Nuclear Fission-Product Spectroscopy (FISSION 2009), May 2009, Saint Paul lez Durance, France. pp.389-392, ⟨10.1063/1.3258257⟩. ⟨in2p3-00432283⟩
  • C. Girerd, D. Autiero, B. Carlus, S. Gardien, J. Marteau, et al.. MicroTCA implementation of synchronous Ethernet-Based DAQ systems for large scale experiments. 2009 Real Time Conference, May 2009, Beijing, China. ⟨in2p3-00394783⟩
  • F. Zimmermann, Y. Papaphilippou, L. Rinolfi, F. Antoniou, R. Chehab, et al.. Stacking Simulations for Compton Positron Sources of Future Linear Colliders. Particle Accelerator Conference (PAC09), May 2009, Vancouver, Canada. pp.MO6RFP064. ⟨in2p3-00382135⟩
  • A. Variola, C. Bruni, O. Dadoun, R. Chehab, M. Kuriki, et al.. ERL Scheme for Compton Polarised Positron Sources. Particle Accelerator Conference (PAC09), May 2009, Vancouver, Canada. pp.MO6RFP068. ⟨in2p3-00382139⟩
  • T. Duguet, T. Lesinski, K. Hebeler, K. Bennaceur, A. Schwenk, et al.. Non-empirical pairing energy functional: lowest-order calculation. Nuclear Structure and Dynamics, May 2009, Dubrovnik, Croatia. ⟨in2p3-00384551⟩
  • M.J. Bajard, C. Peaucelle. Biomolecular Cluster Irradiation System (DIAM). Particle Accelerator Conference (PAC09), May 2009, Vancouver, Canada. ⟨in2p3-00382141⟩
  • L. Rinolfi, F. Antoniou, H.-H. Braun, Y. Papaphilippou, D. Schulte, et al.. The CLIC Positron Source Based on Compton Schemes. Particle Accelerator Conference (PAC 09), May 2009, Vancouver, Canada. pp.WE6RFP065. ⟨in2p3-01182738⟩
  • L. Rinolfi, H.-H. Braun, Y. Papaphilippou, D. Schulte, A. Vivoli, et al.. The CLIC Positron Sources Based on Compton Schemes. Particle Accelerator Conference (PAC09), May 2009, Vancouver, Canada. Triumf Vancouver, pre-press version, pp.WE6RFP065, 2009. ⟨in2p3-00382145⟩

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