Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • N. Chotard, E. Gangler, G. Smadja. Historical and new spectral indicators from the Nearby Supernova Factory. Annual meeting of the French Society of Astronomy and Astrophysics, SF2A-2009, Jun 2009, Besançon, France. pp.203-205. ⟨in2p3-00590627⟩
  • Djamel Dabli, Gerard Montarou, M. Beuve. A microdosimetric analysis of the Geant4 electromagnetic codes for electrons and ions using a microdosimetric concept of the proximity function. Journée Etoile, Jun 2009, Dolomieu, France. ⟨in2p3-00404175⟩
  • B. Depardon, Eddy Caron, Frédéric Desprez, J. Blaizot, H.M. Courtois. Cosmological Simulations on a Grid of Computers. Conference of the Invisible Universe, Jun 2009, Paris, France. pp.816-825, ⟨10.1063/1.3462722⟩. ⟨in2p3-00631723⟩
  • R. Pereira, G. Aldering, P. Antilogus, C. Aragon, S. Bailey, et al.. The Nearby Supernova Factory dataset-improving SNe Ia as dark energy probes. Proceedings of the Conference of the Invisible Universe, Jun 2009, Paris, France. pp.259-266, ⟨10.1063/1.3462644⟩. ⟨in2p3-00589828⟩
  • B. Braunn, M. Labalme, G. Ban, D. Cussol, J.M. Fontbonne, et al.. 12C nuclear reaction measurements for hadrontherapy. 12th International Conference on Nuclear Reaction Mechanisms, Jun 2009, Varenna, Italy. pp.531-537. ⟨in2p3-00449227⟩
  • Olivier Albouy. Discrete algebra and geometry applied to the Pauli group and mutually unbiased bases in quantum information theory. Other [cond-mat.other]. Université Claude Bernard - Lyon I, 2009. English. ⟨NNT : 2009LYO10077⟩. ⟨tel-00612229v2⟩
  • G. Brooijmans, C. Grojean, G.D. Kribs, C. Shepherd-Themistocleous, K. Agashe, et al.. New Physics at the LHC. A Les Houches Report: Physics at TeV Colliders 2009 - New Physics Working Group. 6th Les Houches Workshop: Physics at TeV Colliders, Jun 2009, Les Houches, France. pp.191-380. ⟨in2p3-00482324⟩
  • J. Baudot, R. Barbier, G. Bertolone, A. Besson, A. Brogna, et al.. A New CMOS Sensor Generation for High Energy Physics and Imaging Application. Advancements in Nuclear Instrumentation, Measurement Methods and their Applications (ANIMMA 2009), Jun 2009, Marseille, France. ⟨in2p3-00400367⟩
  • R. Larsen, R. Downing, C. Saunders, V. Pavlicek, T. Jezynski, et al.. ATCA/µTCA for Large Instruments. Advancements in Nuclear Instrumentation, Measurement Methods and their Applications (ANIMMA 2009), Jun 2009, Marseille, France. ⟨in2p3-00400362⟩
  • M. Bajard, M. Chevallier, D. Dauvergne, N. Freud, P. Henriquet, et al.. Prompt Gamma-Ray Monitoring During Carbon Ion Therapy: Comparison Between Measurements and Geant4 Simulations. Advancements in Nuclear Instrumentation, Measurement Methods and their Applications (ANIMMA 2009), Jun 2009, Marseille, France. ⟨in2p3-00400371⟩

Powered by HAL logo