Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Maurice Robert Kibler. In memoriam two distinguished participants of the Bregenz Symmetries in Science Symposia: Marcos Moshinsky and Yurii Fedorovich Smirnov. Symmetries in Science XIV, Jul 2009, Bregenz, Austria. pp.012015, ⟨10.1088/1742-6596/237/1/012015⟩. ⟨in2p3-00452888⟩
  • G. Cacciapaglia, A. Deandrea, J. Llodra-Perez, B. Kubik-Deriaz. Dark Matter from Lorentz Invariance and the LHC. European Physical Society Europhysics Conference on High Energy Physics, EPS-HEP 2009, Jul 2009, Cracow, Poland. 250 (5p.). ⟨in2p3-00589065⟩
  • C. Gaillard, I. Billard, A. Ouadi, G. Wipff, A. Chaumont, et al.. Complexation of U(VI) in room-temperature ionic liquids: competition between two strong ligands. Actinides 2009, Jul 2009, San Francisco, United States. ⟨in2p3-01018333⟩
  • A. Ouadi, E. Jobin, O. Klimchuk, C. Gaillard, I. Billard. Ionic liquids for actinides extraction. Actinides 2009, Jul 2009, San Francisco, United States. ⟨in2p3-01018335⟩
  • S. Scorza. Dark Matter Searches with the Experiment EDELWEISS-II. 12th Marcel Grossmann Meeting (MG12), Jul 2009, Paris, France. pp.879-881. ⟨in2p3-00697046⟩
  • Maurice Robert Kibler. Bases for qudits from a nonstandard approach to SU(2). 13th International Conference on Symmetry Methods in Physics (SYMPHYS XIII), Jul 2009, Dubna, Russia. pp.923-929. ⟨in2p3-00470424⟩
  • H. Abdoul-Carime, Bernadette Farizon, Michel Farizon, E. Illenberger. Dissociative Electron Attachment to Amino-Acids: the case of Leucine. Electron Controlled Chemical Lithography, Jul 2009, Istambul, Turkey. ⟨in2p3-00401810⟩
  • Jan Kisiel, D. Angus, A. Ariga, D. Autiero, A. Apostu, et al.. The LAGUNA project: Towards the giant liquid based detectors for proton decay searches and for low energy neutrino astrophysics. European Physical Society Europhysics Conference on High Energy Physics EPS-HEP 2009, Jul 2009, Cracovie, Poland. pp.283. ⟨in2p3-00704727⟩
  • Veronique Sanglard. EDELWEISS-II Dark Matter search: Status and first results. 11th international conference on Topics in Astroparticle and Underground Physics (TAUP2009), Jul 2009, Rome, Italy. pp.012037, ⟨10.1088/1742-6596/203/1/012037⟩. ⟨hal-00439860⟩
  • J.P. Wieleczko, G. Ademard, Eric Bonnet, A. Chbihi, J.D. Frankland, et al.. Influence of the neutron excess on binary decays in 78,82Kr+40Ca at 5.5 MeV/A reactions. International Conference Nuclear Structure and Related Topics, Jun 2009, Dubna, Russia. pp.118-125. ⟨in2p3-00632512⟩

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