Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J. Argyriades, R. Arnold, C. Augier, J. Baker, A.S. Barabash, et al.. Measurement of the double-β decay half-life of 150Nd and search for neutrinoless decay modes with the NEMO-3 detector. Physical Review C, 2009, 80, pp.032501. ⟨10.1103/PhysRevC.80.032501⟩. ⟨in2p3-00427207⟩
  • X. Artru. Recursive fragmentation model with quark spin. Application to quark polarimetry. XIII Workshop on High Energy Spin Physics, DSPIN 2009, Sep 2009, Dubna, Russia. ⟨in2p3-00441764⟩
  • M. Fallavier, B. Canut, E. Calvie, D. Albertini. Ion emission of a-SiO2/c-Si targets under Au9+ cluster impact. 15th international symposium "Radiation Effects in Insulators" - REI 15, Aug 2009, Padova, Italy. ⟨in2p3-00589306⟩
  • Bernard Borderie, Eric Bonnet, N. Le Neindre, S. Piantelli, Ad. R. Raduta, et al.. The prominent role of the heaviest fragment in multifragmentation and phase transition for hot nuclei. International Workshop on Nuclear Dynamics in Heavy-Ion Reactions and the Symmetry Energy (IWND2009), Aug 2009, Shanghai, China. pp.1523-1533, ⟨10.1142/S0218301310015928⟩. ⟨hal-00461309⟩
  • E. Galichet, Marie-France Rivet, B. Borderie, M. Colonna, R. Bougault, et al.. Isospin diffusion in 58Ni-induced reactions at intermediate energies. International workshop on nuclear dynamics in heavy-ion reactions and the symmetry energy, Aug 2009, Shanghai, China. pp.1534, ⟨10.1142/S021830131001593X⟩. ⟨in2p3-00461302⟩
  • I. Billard, C. Gaillard, S. Georg. First determination of successive complexation constants in an ionic liquid: The UO22+/NO3- system in C4-mimTf2N as studied by UV-vis and chemometric methods. 31st International Conference on Solution Chemistry, Aug 2009, Innsbruck, Austria. ⟨in2p3-01018337⟩
  • Gerald P. Niccolai, Jean-Paul Allagnat, Sébastien Buthion, Jacques Fontès, Daniel Guinet, et al.. Studies on project documentation and transmission and the battle against re-innovation. 238th National Meeting of the American Chemical Society, Aug 2009, Washington DC, France. ⟨halshs-00429279⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Combined measurements of anomalous charged trilinear gauge-boson couplings from diboson production in p-pbar collisions at sqrt(s)=1.96 TeV. 2009. ⟨in2p3-00408118⟩
  • J. Argyriades, R. Arnold, C. Augier, J. Baker, A. S. Barabash, et al.. Measurement of the background in the NEMO 3 double beta decay experiment. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2009, 606, pp.449-465. ⟨10.1016/j.nima.2009.04.011⟩. ⟨in2p3-00378540⟩
  • S. Marnieros, E. Armengaud, C. Augier, L. Berge, A. Benoit, et al.. Full Inter-Digitized Detectors For The EDELWEISS-II Dark Matter Search. 13th International Workshop on Low Temperature Detectors, Jul 2009, Stanford, United States. pp.635-638. ⟨in2p3-00681379⟩

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