Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • T. Thuillier, T. Lamy, C. Peaucelle, P. Sortais. Status report of the heavy ions source research and development for Spiral2. The 13th International Conference on Ion Sources (ICIS'09), Sep 2009, Gatlinburg, United States. pp.02A316, ⟨10.1063/1.3273061⟩. ⟨in2p3-00423865⟩
  • R. Gaglione, C. Adloff, M. Chefdeville, C. Drancourt, G. Vouters. DIRAC v2: a DIgital Readout Asic for hadronic Calorimeter. Topical Workshop on Electronics for Particle Physics (TWEPP-09), Sep 2009, Paris, France. pp.117-121. ⟨in2p3-00420247⟩
  • S. Crampon, G. Bohner, Hervé Chanal, J. Lecoq, H. Mathez, et al.. The 8 bits 100 MS/s Pipeline ADC for the INNOTEP Project – TWEPP-09. TWEPP-09 Topical Workshop on Electronics for Particle Physics Search, Sep 2009, Paris, France. ⟨in2p3-00428589⟩
  • M. Beuve, L. Chollier, Djamel Dabli, D. Dauvergne, Gerard Montarou, et al.. Modélisation des effets radiobiologiques pour l'hadronthérapie: étude du modèle de Katz. 9eme Colloque International de Radiobiologie Fondamentale et Appliquée, Sep 2009, Annecy, France. ⟨in2p3-00426847⟩
  • C.-E. Vaudey, N. Toulhoat, N. Moncoffre, N. Bérerd. Chlorine speciation in nuclear graphite: consequences on temperature release and on leaching. Migration 2009, Sep 2009, Kennewick, United States. pp.667-673, ⟨10.1524/ract.2010.1767⟩. ⟨in2p3-00663448⟩
  • Djamel Dabli, Gerard Montarou, M. Beuve, C. Rodriguez-Lafrasse. Application de la microdosimétrie pour le calcul de la survie cellulaire pour des cellules irradiées avec des particules à haut TEL. 9eme Colloque International de Radiobiologie Fondamentale et Appliquée, Sep 2009, Annecy, France. ⟨in2p3-00426832⟩
  • Élisabeth Fiat Massot. Description relativiste chirale de la matière nucléaire incluant des effets de confinement du nucléon. Autre [cond-mat.other]. Université Claude Bernard - Lyon I, 2009. Français. ⟨NNT : 2009LYO10128⟩. ⟨tel-00442137v2⟩
  • R. Bes, N. Millard-Pinard, S. Gavarini, Sandrine Cardinal, V. Garnier, et al.. Study of xenon thermal migration in sintered titanium nitride using nuclear micro-probe. 19th International Conference on Ion Beam Analysis, Sep 2009, Cambridge, UK, United States. pp.1880-1883, ⟨10.1016/j.nimb.2010.02.018⟩. ⟨in2p3-00487017⟩
  • J.-M. Richard. Elusive multiquark spectroscopy. IUPAP Conference on Few-Body Problems in Physics, Sep 2009, Bonn, Germany. pp.01015, ⟨10.1051/epjconf/20100301015⟩. ⟨in2p3-00444670v2⟩
  • Vincent Baudet, Michael Beuve, Fabrice Jaillet, B. Shariat, Florence Zara. Integrating Tensile Parameters in Mass-Spring System for Deformable Object Simulation. 2009. ⟨hal-01493735⟩

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