Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
546 documents

  • G. Alphonse, M. Hanot, G. Bertrand, A. Boivin, M. Maalouf, et al.. Targeting the main causes of recurrence in head and neck squamous cell carcinoma to overcome resistance to carbon ion radiation. 8èmes journées scientifiques du CLARA, Mar 2013, Lyon, France. ⟨hal-00854790⟩
  • S. Ferrandon, J. Carras, P. Battiston-Montagne, G. Alphonse, M. Beuve, et al.. Statut télomérique: vers une prise en charge personnalisée du glioblastome. 8èmes journées scientifiques du CLARA, Mar 2013, Lyon, France. ⟨hal-00854992⟩
  • P. Manescu, J. Azencot, M. Beuve, H. Ladjal, B. Shariat. Patient Multi-Physics Modeling for Particle Therapy Simulations. 8èmes journées scientifiques du CLARA, Mar 2013, Lyon, France. ⟨hal-00855031⟩
  • M.-A. Chanrion, W. Sauerwein, U. Jelen, A. Wittig, C. Engenhart, et al.. Influence of the local effect model parameters on the tumor control probability for prostate cancer. 8èmes journées scientifiques du CLARA, Mar 2013, Lyon, France. ⟨hal-00854875⟩
  • J. Constanzo, M. Fallavier, G. Alphonse, C. Bernard, P. Montagne, et al.. Radiobiological studies with the low energy protons of the Radiograaff platform. 8èmes journées scientifiques du CLARA, Mar 2013, Lyon, France. ⟨hal-00854892⟩
  • G. Alphonse, M. Maalouf, P. Battiston-Montagne, D. Ardail, M. Beuve, et al.. p53-independent early and late apoptosis is mediated by ceramide after exposure of tumor cells to photon or carbon ion irradiation. BMC Cancer, 2013, 13, pp.151. ⟨10.1186/1471-2407-13-151⟩. ⟨hal-00850652⟩
  • S. Rit, G. Dedes, N. Freud, D. Sarrut, J.-M. Letang. Filtered backprojection proton CT reconstruction along most likely paths. Medical Physics : The international journal of medical physics research and practice, 2013, 40 (3), pp.031103. ⟨10.1118/1.4789589⟩. ⟨hal-00796949⟩
  • S. Ferrandon, P. Saultier, J. Carras, P. Battiston-Montagne, G. Alphonse, et al.. Telomere profiling : toward glioblastoma personalized medicine. Molecular Neurobiology, 2013, 47 (1), pp.64-76. ⟨10.1007/s12035-012-8363-9⟩. ⟨hal-00828504⟩
  • H. Zhou, M. Beuve, F. Yang, N.-B. Wong, W.-K. Li. Theoretical investigation on the cylinder-shaped N66 cage. Computational and Theoretical Chemistry, 2013, 1005, pp.68-74. ⟨10.1016/j.comptc.2012.11.007⟩. ⟨in2p3-00874755⟩
  • G. Dedes, S. Rit, D. Dauvergne, M. de Rydt, N. Freud, et al.. Electron density resolution determination and systematic uncertainties in proton computed tomography (pcT). IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Oct 2012, Anaheim, United States. ⟨10.1109/NSSMIC.2012.6551586⟩. ⟨hal-01149111⟩

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