Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. Bender, K. Bennaceur, T. Duguet, P. -H. Heenen, T. Lesinski, et al.. Tensor part of the Skyrme energy density functional. II: Deformation properties of magic and semi-magic nuclei. Physical Review C, 2009, 80, pp.064302. ⟨10.1103/PhysRevC.80.064302⟩. ⟨in2p3-00440670⟩
  • F. Chassagneux, L. Bois, S. Parola, F. Bessueille, Y. Battie, et al.. Silver nanoparticles inside a mesoporous titania template and photochromism properties. Vingt-deuxièmes entretiens Jacques Cartier, Connecting to the nanoworld, Nov 2009, Ecully, France. ⟨ujm-00431194⟩
  • R. Kieffer. Un calorimètre hadronique semi-digital pour l'ILC (SDHCAL). JournĂ©es de Rencontre Jeunes Chercheurs 2009 (JRJC 2009), Nov 2009, Barbaste, France. pp.155-158. ⟨in2p3-00583168⟩
  • N. Chotard. Historical and new spectral indicators from the Nearby Supernova Factory. JournĂ©es de Rencontre Jeunes Chercheurs 2009 (JRJC 2009), Nov 2009, Barbaste, France. pp.115-116. ⟨in2p3-00579580⟩
  • H. Brun. La mesure de l'Ă©nergie des photons dans CMS - Application Ă  la dĂ©couverte du boson de Higgs dans le canal H \rightarrow \gamma\gamma. JournĂ©es de Rencontre Jeunes Chercheurs 2009 (JRJC 2009), Nov 2009, Barbaste, France. pp.209-212. ⟨in2p3-00583171⟩
  • M. C. Ruivo, Pedro Costa, H. Hansen, C. A. de Sousa. Exploring the role of model parameters and regularization procedures in the thermodynamics of the PNJL model. XIII International Conference on Hadron Spectroscopy (Hadron 2009), Nov 2009, Tallahassee (FL), United States. pp.681-685, ⟨10.1063/1.3483419⟩. ⟨in2p3-00589073⟩
  • M. C. Ruivo, Pedro Costa, C. A. de Sousa, H. Hansen, W. M. Alberico. How the Polyakov loop and the regularization affect strangeness and restoration of symmetries at finite T. XIII International Conference on Hadron Spectroscopy (HADRON 2009), Nov 2009, Tallahassee (FL), United States. pp.770-774, ⟨10.1063/1.3483439⟩. ⟨in2p3-00589074⟩
  • L. Massacrier. Etude d'un tĂ©lescope Ă  vertex pour le spectromètre Ă  muons de l'expĂ©rience ALICE au LHC. JournĂ©es de Rencontre Jeunes Chercheurs 2009 (JRJC 2009), Nov 2009, Barbaste, France. pp.289-293. ⟨in2p3-00579588⟩
  • Y. Tschudi. Recherche de SUperSYmĂ©trie et reconstruction des traces cosmiques dans l'expĂ©rience CMS au LHC. JournĂ©es de Rencontre Jeunes Chercheurs 2009 (JRJC 2009), Nov 2009, Barbaste, France. pp.101-105. ⟨in2p3-00583160⟩
  • N. Chanon. Discrimination \gamma/\pi^0 pour la recherche du boson de Higgs dans le canal H \rightarrow \gamma\gamma dans l'expĂ©rience CMS. JournĂ©es de Rencontre Jeunes Chercheurs (JRJC 2009), Nov 2009, Barbaste, France. pp.213-217. ⟨in2p3-00583176⟩

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