Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J. Tabet, S. Eden, S. Feil, H. Abdoul-Carime, M. Farizon, et al.. Absolute molecular flux and angular distribution measurements to characterize DNA / RNA vapor jets. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2010, 268, pp.2458-2466. ⟨10.1016/j.nimb.2010.05.005⟩. ⟨in2p3-00462417⟩
  • G. Cacciapaglia, A. Deandrea, J. Llodra-Perez. A Dark Matter candidate from Lorentz Invariance in 6 Dimensions. Journal of High Energy Physics, 2010, 1003, pp.083. ⟨10.1007/JHEP03(2010)083⟩. ⟨in2p3-00589016⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Dependence of the t\bar{t} production cross section on the transverse momentum of the top quark. Physics Letters B, 2010, 693, pp.515-521. ⟨10.1016/j.physletb.2010.09.011⟩. ⟨in2p3-00446556⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for single top quarks in the tau+jets channel using 4.8 fb^{-1} of p\bar{p} collision data. Physics Letters B, 2010, 690, pp.5-14. ⟨10.1016/j.physletb.2010.05.003⟩. ⟨in2p3-00439944⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for scalar bottom quarks and third-generation leptoquarks in ppbar collisions at sqrt(s) = 1.96 TeV. Physics Letters B, 2010, 693, pp.95-101. ⟨10.1016/j.physletb.2010.08.028⟩. ⟨in2p3-00483886⟩
  • C. Gaillard, A. Chaumont, I. Billard, C. Hennig, A. Ouadi, et al.. Competitive Complexation of Nitrates and Chlorides to Uranyl in a Room Temperature Ionic Liquid. Inorganic Chemistry, 2010, 49, pp.6484-6494. ⟨10.1021/ic100170t⟩. ⟨in2p3-00589500⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for CP violation in Bs0→Ό+Ds-X decays in pp̅ collisions at √s=1.96  TeV. Physical Review D, 2010, 82, pp.012003. ⟨10.1103/PhysRevD.82.012003⟩. ⟨in2p3-00378781⟩
  • Claire Guipponi. Effets de la radiolyse de l'air humide et de l'eau sur la corrosion de la couche d'oxyde du Zircaloy-4 oxydĂ©. Autre [q-bio.OT]. UniversitĂ© Claude Bernard - Lyon I, 2009. Français. ⟨NNT : 2009LYO10298⟩. ⟨tel-00490984v2⟩
  • O. StĂ©zowski. La spectroscopie gamma de EUROGAM Ă  AGATA. 26Ăšme JournĂ©es ThĂ©matiques de l'IPN Orsay, "L'impact des rĂ©volutions informatiques sur la physique et les techniques nuclĂ©aires", Dec 2009, Orsay, France. ⟨in2p3-00990101⟩
  • ClĂ©ment Buton. Étalonnage spectro-photomĂ©trique du SuperNova Integral Field Spectrograph dans le cadre du projet the Nearby Supernova Factory. Autre. UniversitĂ© Claude Bernard - Lyon I, 2009. Français. ⟨NNT : 2009LYO10303⟩. ⟨tel-00465853v2⟩

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