Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
546 documents

  • P. Manescu, H. Ladjal, Joseph Azencot, M. Beuve, B. Shariat. Biomechanical-based respiratory motion-compensation for 4D dose calculation during hadron therapy. 27th International Congress and Exhibition, Computer Assisted Radiology, Jun 2013, Heidelberg, Germany. pp.39-44, ⟨10.1007/s11548-013-0849-z⟩. ⟨hal-00850636⟩
  • J. Krimmer, L. Balleyguier, J. Baudot, S. Brons, L. Caponetto, et al.. Real-Time Online Monitoring of the Ion Range by Means of Prompt Secondary Radiations. 3rd International Conference On Advancements In Nuclear Instrumentation Measurement Methods And Their Applications (ANIMMA 2013), Jun 2013, Marseille, France. pp.1-8, ⟨10.1109/ANIMMA.2013.6728046⟩. ⟨hal-00873701⟩
  • G. Alphonse, D. Ardail, E. Armandy, M. Bajard, J. Balosso, et al.. 2012 Activity Report of the Regional Research Programme on Hadrontherapy for the ETOILE Center. [Research Report] Centre Etoile; Université Lyon 1 - Claude Bernard. 2013. ⟨hal-00840163⟩
  • W. Enghardt, D. Dauvergne, J. Barrio, C. Cabello, J. Gillam, et al.. Monitoring the Bragg peak during ion therapy by means of prompt radiation. The ENVISION program. 52nd Annual Conference of the Particle Therapy Co-Operative Group, Jun 2013, Essen, Germany. ⟨hal-00838430⟩
  • V. Reithinger, J. Baudot, S. Brons, D. Dauvergne, G. Dedes, et al.. Proton Interaction Vertex Imaging With Silicon-Pixel CMOS Telescope For Carbon Therapy Quality Control. 52nd Annual Conference of the Particle Therapy Co-Operative Group, Jun 2013, Essen, Germany. ⟨hal-00838442⟩
  • M. Pinto, D. Dauvergne, M. de Rydt, G. Dedes, N. Freud, et al.. Online particle therapy monitoring using prompt-gamma radiation: collimated camera design with TOF. 52nd Annual Conference of the Particle Therapy Co-Operative Group, Jun 2013, Essen, Germany. ⟨hal-00838456⟩
  • P. Gueth, D. Dauvergne, N. Freud, J.-M. Létang, C. Ray, et al.. Machine-learning-based patient specific prompt-gamma dose monitoring in protontherapy. 52nd Annual Conference of the Particle Therapy Co-Operative Group, Jun 2013, Essen, Germany. ⟨hal-00838405⟩
  • M.-A. Chanrion, U. Jelen, A. Wittig, R. Engenhart-Cabillic, M. Beuve, et al.. Assessment of the influence of the the Local Effect Model input parameters on tumor control probability for prostate carbon ion therapy treatment plans. 52nd Annual Conference of the Particle Therapy Co-Operative Group, Jun 2013, Essen, Germany. ⟨hal-00838452⟩
  • P. Manescu, H. Ladjal, Joseph Azencot, M. Beuve, B. Shariat. Human Liver Multiphysics Modeling for 4D Dosimetry During Hadrontherapy. IEEE International Symposium on Biomedical Imaging (ISBI2013), Apr 2013, San Francisco, United States. pp.472-475, ⟨10.1109/ISBI.2013.6556514⟩. ⟨hal-00850626⟩
  • G. Alphonse, M. Hanot, G. Bertrand, A. Boivin, M. Maalouf, et al.. Targeting the main causes of recurrence in head and neck squamous cell carcinoma to overcome resistance to carbon ion radiation. 8èmes journées scientifiques du CLARA, Mar 2013, Lyon, France. ⟨hal-00854790⟩

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