Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Farvah Mahmoudi. Reconstructing MSSM Parameters from Higgs Searches. Strong dynamics for physics within and beyond the Standard Model at LHC and Future Colliders, Sep 2019, Trento, Italy. pp.86-90. ⟨hal-02550045⟩
    • S. Mariazzi, R. Caravita, A. Vespertini, A. Camper, B. Rienacker, et al.. Techniques for Production and Detection of 2^3S Positronium. 15th International Workshop on Slow Positron Beam Techniques and Applications, Sep 2019, Prague, Czech Republic. pp.91-95, ⟨10.12693/APhysPolA.137.91⟩. ⟨hal-02564659⟩
    • Benedetta Nodari, Gianmario Bergamin, Luigi Caponetto, Alessandro Caratelli, Davide Ceresa, et al.. First results from the CIC data aggregation ASIC for the Phase 2 CMS Outer Tracker. Topical Workshop on Electronics for Particle Physics, Sep 2019, Santiago de Compostela, Spain. pp.102, ⟨10.22323/1.370.0102⟩. ⟨hal-02572520⟩
    • Simone Scarfi, Gianmario Bergamin, Alessandro Caratelli, Luigi Caponetto, Davide Ceresa, et al.. Study of a Triggered, Full Event Zero-Suppressed Front-End Readout Chain operating up to 1 MHz Trigger Rate and Pileup of 300 for CMS Outer Tracker upgrade at HL-LHC. Topical Workshop on Electronics for Particle Physics, Sep 2019, Santiago de Compostela, Spain. pp.012, ⟨10.22323/1.370.0012⟩. ⟨hal-02572513⟩
    • Xiushan Chen, C. Combaret, C. Girerd, C. Guerin, I. Laktineh, et al.. Multi-channel time-tagging module for fast-timing Resistive Plate Chamber detectors. Topical Workshop on Electronics for Particle Physics, Sep 2019, Santiago de Compostela, Spain. pp.093, ⟨10.22323/1.370.0093⟩. ⟨hal-02572519⟩
    • R. Caravita, M. Antonello, A. Belov, G. Bonomi, R.S. Brusa, et al.. Hybrid Imaging and Timing Ps Laser Excitation Diagnostics for Pulsed Antihydrogen Production. 15th International Workshop on Slow Positron Beam Techniques and Applications, Sep 2019, Prague, Czech Republic. pp.96-100, ⟨10.12693/APhysPolA.137.96⟩. ⟨hal-02564658⟩
    • H. Moriya, W. Horiuchi, J.-M. Richard. Three-body correlations in mesonic-atom-like systems. 24th European Conference on Few-Body Problems in Physics, Sep 2019, Surrey, United Kingdom. pp.051, ⟨10.21468/SciPostPhysProc.3.051⟩. ⟨hal-02423737⟩
    • C. Verry, E. Porcel, C. Chargari, C. Rodriguez-Lafrasse, J. Balosso. Utilisation de nanoparticules comme agent radiosensibilisant en radiothérapie : où en est-on ?. Cancer/Radiothérapie, 2019, 23 (8), pp.917-921. ⟨10.1016/j.canrad.2019.07.134⟩. ⟨hal-02309383⟩
    • Dimitrios Tsimpis. Consistent truncation on Calabi-Yau and Nearly-Kähler manifolds. 19th Hellenic School and Workshops on Elementary Particle Physics and Gravity, Aug 2019, Corfu, Greece. pp.122, ⟨10.22323/1.376.0122⟩. ⟨hal-02504614⟩
    • Safa Louati, Anne‐sophie Wozny, Jean-Baptiste Guy, Ladjohounlou Riad, Céline Malésys, et al.. Deciphering the role of stress granules in the cellular response to radiation of HNSCC cancer cells. ICRR 2019, Aug 2019, Manchester, United Kingdom. ⟨hal-02358809⟩

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