Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
476 documents

  • C. Gautherin, W. Korten, Y. Le Coz, R. Lucas, X.H. Phan, et al.. Study of isomeric states in neutron-rich nuclei produced by spontaneous fission of^{252}Cf. International school of nuclear physics, Sep 1996, Erice, Italy. pp.289-290. ⟨in2p3-00000035⟩
  • P. Willsau, M. Neffgen, Y. Le Coz, H. Hubel, W. Korten, et al.. Lifetimes of a dipole cascade in ^{192}Hg. Zeitschrift für Physik. A, Atoms and Nuclei, 1996, 355, pp.129-134. ⟨in2p3-00012969⟩
  • A. Lopez-Martens, F. Hannachi, T. Dossing, C. Schuck, R. Collatz, et al.. Fragmentation of the decay from the superdeformed yrast band in ^{192}Hg. Physical Review Letters, 1996, 77, pp.1707-1710. ⟨in2p3-00009593⟩
  • M. Kaci, M.G. Porquet, F. Hannachi, M. Aiche, G. Bastin, et al.. Dipole bands in the oblate-shaped ^{195}Pb. Zeitschrift für Physik. A, Atoms and Nuclei, 1996, 354, pp.267-275. ⟨in2p3-00009591⟩
  • L. Beaulieu, D.R. Bowman, D. Fox, S. das Gupta, J. Pan, et al.. Source size scaling of fragment production in projectile breakup. Physical Review C, 1996, 54, pp.R973-R976. ⟨in2p3-00002440⟩
  • L. Beaulieu, Y. Larochelle, L. Gingras, G.C. Ball, D.R. Bowman, et al.. Direct measurement of dissipation in the ^{35}Cl + ^{12}C reaction at 43 mev/nucleon. Physical Review Letters, 1996, 77, pp.462-465. ⟨in2p3-00012932⟩
  • S. Bouneau, A.N. Wilson, F. Azaiez, J.F. Sharpey-Schafer, A. Korichi, et al.. Proton excitations in the sd nuclei of the mass 190 region. High Angular Momentum Phenomena Workshop In Honour Of Zdzislaw Szymanski, Aug 1995, Piaski, Poland. pp.197-204. ⟨in2p3-00012953⟩
  • M.G. Porquet, F. Azaiez, J.F. Sharpey-Schafer, A. Astier, G. Bastin, et al.. Fission induced by heavy ions: new results from EUROGAM array. High Angular Momentum Phenomena,Workshop In Honour Of Zdzislaw Szymanski, Aug 1995, Piaski, Poland. pp.179-185. ⟨in2p3-00007530⟩
  • A.N. Willson, J. Timar, J.F. Sharpey-Schafer, B. Crowell, M.P. Carpenter, et al.. First evidence of collective vibrations of superdeformed nuclei. Divisional Conference on Low-Energy Nuclear Dynamics 15, Apr 1995, St. Petersburg, Russia. pp.545-552. ⟨in2p3-00014575⟩
  • J.F. Sharpey-Schafer, A.N. Wilson, J. Timar, B. Crowell, S. Bouneau, et al.. Exotic superdeformed structures in A approximately 190 nuclei observed using EUROGAM2. International Winter Meeting on Nuclear Physics 33, Jan 1995, Bormio, Italy. pp.21-38. ⟨in2p3-00013217⟩

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