Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of Z/gamma*+jet+X$ angular distributions in ppbar collisions at sqrt{s}=1.96 TeV. Physics Letters B, 2010, 682, pp.370-380. ⟨10.1016/j.physletb.2009.11.012⟩. ⟨in2p3-00409922⟩
  • D. Sillou, M. Besancon, M. Dejardin, D. Denegri, B. Fabbro, et al.. Search for Dijet Resonances in 7 TeV pp Collisions at CMS. Physical Review Letters, 2010, 105, pp.211801. ⟨10.1103/PhysRevLett.105.211801⟩. ⟨in2p3-00525737⟩
  • D. Sillou, M. Besancon, M. Dejardin, D. Denegri, B. Fabbro, et al.. Search for Quark Compositeness with the Dijet Centrality Ratio in pp Collisions at sqrt(s)=7 TeV. Physical Review Letters, 2010, 105, pp.262001. ⟨10.1103/PhysRevLett.105.262001⟩. ⟨in2p3-00534073⟩
  • Ngoc-Long Do, N. Bérerd, N. Moncoffre, D. Gorse-Pomonti. Damage generated by MeV-ion beams on titanium surface in oxidizing environment. 2010 MRS Fall Meeting - Symposium Q/R/T - Advanced Materials for Applications in Extreme Environments, 2010, Boston, United States. ⟨10.1557/opl.2011.372⟩. ⟨in2p3-00734357⟩
  • C.E Vaudey, N. Toulhoat, N. Moncoffre, N. Bérerd. Effets de la température et de la radiolyse sur la distribution et la spéciation du chlore dans le graphite nucléaire. Journées annuelles du GNR PARIS, 2010, Avignon, France. ⟨in2p3-01018520⟩
  • J. Dupuis, E. Fourmond, D. Ballutaud, N. Bererd, M. Lemiti. Optical and structural properties of silicon oxynitride deposited by plasma enhanced chemical vapor deposition. Thin Solid Films, 2010, 519, pp.1325-1333. ⟨10.1016/j.tsf.2010.09.036⟩. ⟨in2p3-00734027⟩
  • O. Stézowski. Informatique, simulation et analyse. Ecole IN2P3 d'instrumentation "de la physique au détecteur", 2010, Fréjus, France. ⟨in2p3-00765343⟩
  • C.-E. Vaudey, N. Toulhoat, N. Moncoffre, N. Bérerd, C. Peaucelle. Use of a gas irradiation cell to study the effects of nuclear graphite radiolytic corrosion on the behaviour of chlorine. E-MRS 2010, 2010, Strasbourg, France. ⟨in2p3-01018341⟩
  • Maurice R. Kibler. Bases for spin systems and qudits from angular momentum theory. Communications in Nonlinear Science and Numerical Simulation, 2010, 15, pp.752-763. ⟨10.1016/j.cnsns.2009.05.017⟩. ⟨in2p3-00333758⟩
  • J. A. Garcia, L. I. Gascon, Elías Cueto, Francisco Chinesta. Applications of Proper Generalized Decomposition in Material Forming Process Simulation. Seventh International Conference on Engineering Computational Technology, 2010, Valencia, Spain. ⟨hal-01007901⟩

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