Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- J.-M. Richard. Multiquarks and Steiner trees. Nuclear Physics B - Proceedings Supplements, 2010, 207, pp.371-374. ⟨10.1016/j.nuclphysbps.2010.10.096⟩. ⟨in2p3-00525240⟩
- Sacha Davidson, G. Grenier. Lepton flavor violating Higgs bosons and tau to mu gamma. Physical Review D, 2010, 81, pp.095016. ⟨10.1103/PhysRevD.81.095016⟩. ⟨in2p3-00444082⟩
- N. Agafonova, A. Anokhina, S. Aoki, A. Ariga, T. Ariga, et al.. Measurement of the atmospheric muon charge ratio with the OPERA detector. European Physical Journal C: Particles and Fields, 2010, 67 (1-2), pp.25-37. ⟨10.1140/epjc/s10052-010-1284-8⟩. ⟨in2p3-00462507⟩
- V. Khachatryan, A.M. Sirunyan, A. Tumasyan, W. Adam, T. Bergauer, et al.. Measurement of the charge ratio of atmospheric muons with the CMS detector. Physics Letters B, 2010, 692, pp.83-104. ⟨10.1016/j.physletb.2010.07.033⟩. ⟨in2p3-00487914⟩
- V. Khachatryan, A.M. Sirunyan, A. Tumasyan, W. Adam, T. Bergauer, et al.. Measurement of the Underlying Event Activity in Proton-Proton Collisions at 0.9 TeV. European Physical Journal C: Particles and Fields, 2010, 70, pp.555-572. ⟨10.1140/epjc/s10052-010-1453-9⟩. ⟨in2p3-00491725⟩
- Maurice Robert Kibler. Formulas for Mutually Unbiased Bases in Systems of Qudits. A. Sakaji, I. Licata, J. Singh, and S. Felloni. New Trends in Quantum Information, Aracne editrice, pp.191-210, 2010. ⟨in2p3-00589646⟩
- G. Macorini, S. Moretti, L. Panizzi. Strong and Electro-Weak Supersymmetric Corrections to Single Top Processes at the Large Hadron Collider. Physical Review D, 2010, 82, pp.054016. ⟨10.1103/PhysRevD.82.054016⟩. ⟨in2p3-00521792⟩
- Michel Planat, Maurice R. Kibler. Unitary reflection groups for quantum fault tolerance. Journal of computational and theoretical nanoscience, 2010, 7, pp.1759-1770. ⟨hal-00305181v3⟩
- V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for a resonance decaying into WZ boson pairs in
collisions. Physical Review Letters, 2010, 104, pp.061801. ⟨10.1103/PhysRevLett.104.061801⟩. ⟨in2p3-00438558⟩ - K. Aamodt, N. Abel, U. Abeysekara, A. Abrahantes Quintana, A. Abramyan, et al.. Midrapidity antiproton-to-proton ratio in pp collisions at
and 
~TeV measured by the ALICE experiment. Physical Review Letters, 2010, 105, pp.072002. ⟨10.1103/PhysRevLett.105.072002⟩. ⟨in2p3-00495865⟩
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