Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • F. Le Foulher, M. Bajard, M. Chevallier, D. Dauvergne, N. Freud, et al.. Monte Carlo simulations of prompt-gamma emission during carbon ion irradiation. IEEE Transactions on Nuclear Science, 2010, 57 (5), pp.2768-2772. ⟨in2p3-00480024⟩
  • J. Tabet, S. Eden, S. Feil, H. Abdoul-Carime, B. Farizon, et al.. Absolute total and partial cross sections for ionization of nucleobases by proton impact in the Bragg peak velocity range. Physical Review A : Atomic, molecular, and optical physics [1990-2015], 2010, 82, pp.022703. ⟨10.1103/PhysRevA.82.022703⟩. ⟨in2p3-00408267⟩
  • G. Cacciapaglia. Beyond the Standard Model: Supersymmetry and Extra Dimensions. Vietnam Summer School in High Energy Physics, 2010, Hanoi, Vietnam. ⟨in2p3-01023958⟩
  • S. Chatrchyan, P. Nedelec, D. Sillou, M. Besancon, R. Chipaux, et al.. Aligning the CMS Muon Chambers with the Muon Alignment System during an Extended Cosmic Ray Run. Journal of Instrumentation, 2010, 5(03), pp.T03019. ⟨10.1088/1748-0221/5/03/T03019⟩. ⟨in2p3-00664862⟩
  • G. Cacciapaglia. Dark Matter from Lorentz Invariance in 6 Dimensions. Meeting of the project Theorie LHC France, GDR Terascale Tools, FCPPL Hadron Satellite, 2010, Lyon, France. ⟨in2p3-01023935⟩
  • Pedro Costa, H. Hansen, M. C. Ruivo, C. A. de Sousa. How parameters and regularization affect the PNJL model phase diagram and thermodynamic quantities. Physical Review D, 2010, 81, pp.016007. ⟨10.1103/PhysRevD.81.016007⟩. ⟨in2p3-00589077⟩
  • T. Lepers, D. Davesne, S. Chiacchiera, Michael Urban. Numerical solution of the Boltzmann equation for the collective modes of trapped Fermi gases. Physical Review A : Atomic, molecular, and optical physics [1990-2015], 2010, 82, pp.023609. ⟨10.1103/PhysRevA.82.023609⟩. ⟨in2p3-00497533⟩
  • M. Testa, M. Bajard, M. Chevallier, D. Dauvergne, N. Freud, et al.. Physical measurements for real time monitoring of the Bragg peak location by means of single photon detection. 12th International Workshop on Radiation Imaging Detectors, 2010, Cambridge, United Kingdom. ⟨in2p3-00778976⟩
  • M. R. Kibler. Formula for unbiased bases. 6th International Microconference on Analytic and Algebraic Methods in Physics, 2010, Prague, Czech Republic. ⟨in2p3-00740585⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of the dijet invariant mass cross section in proton anti-proton collisions at sqrt{s} = 1.96 TeV. Physics Letters B, 2010, 693, pp.531-538. ⟨10.1016/j.physletb.2010.09.013⟩. ⟨in2p3-00460299⟩

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