Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Ngoc-Long Do, N. Bérerd, N. Moncoffre, D. Gorse-Pomonti. Damage generated by MeV-ion beams on titanium surface in oxidizing environment. 2010 MRS Fall Meeting - Symposium Q/R/T - Advanced Materials for Applications in Extreme Environments, 2010, Boston, United States. ⟨10.1557/opl.2011.372⟩. ⟨in2p3-00734357⟩
  • M. Martini, M. Ericson, G. Chanfray, J. Marteau. Neutrino and antineutrino quasielastic interactions with nuclei. Physical Review C, 2010, 81, pp.045502. ⟨10.1103/PhysRevC.81.045502⟩. ⟨in2p3-00459569⟩
  • N. Agafonov, Alexander Aleksandrov, O. Altinok, M. Ambrosio, A. Anokhina, et al.. Observation of a first \nu_\tau candidate in the OPERA experiment in the CNGS beam. Physics Letters B, 2010, 691, pp.138-145. ⟨10.1016/j.physletb.2010.06.022⟩. ⟨in2p3-00491644⟩
  • Pierre Labéguerie, Moussab Harb, Isabelle Baraille, Michel Rérat. Structural, electronic, elastic, and piezoelectric properties of α -quartz and M X O 4 ( M = Al , Ga, Fe; X = P , As) isomorph compounds: A DFT study. Physical Review B, 2010, 81 (4), ⟨10.1103/PhysRevB.81.045107⟩. ⟨hal-03227499⟩
  • Francesca Lanata, Franck Schoefs, Katheirne Le. Statistical identification via Polynomial Chaos expansion and Markov Chain Monte Carlo methods. 4th European Conference on Computational Mechanics, ECCM'010, 2010, Paris, France. ⟨hal-01008951⟩
  • Franck Schoefs, Vikram Pakrashi, Bidisha Ghosh. Mesure de la fiabilité de détection des défauts par analyse d'image par courbes ROC. Journées Scientifiques de l'Université de Nantes, 2010, Nantes, France. ⟨hal-01008413⟩
  • Francisco Chinesta, Brice Bognet, Arnaud Poitou, Adrien Leygue, Elías Cueto. When the solution of 3D models only involves 2D complexity. 9th World Congress on Computational Mechanics, 2010, Sydney, Australia. ⟨hal-01009112⟩
  • K. Aamodt, N. Abel, U. Abeysekara, A. Abrahantes Quintana, A. Acero, et al.. First proton--proton collisions at the LHC as observed with the ALICE detector: measurement of the charged particle pseudorapidity density at \ sqrt(s)= 900 GeV. European Physical Journal C: Particles and Fields, 2010, 65, pp.111-125. ⟨10.1140/epjc/s10052-009-1227-4⟩. ⟨in2p3-00437986⟩
  • K. Aamodt, N. Abel, U. Abeysekara, A. Abrahantes Quintana, A. Abramyan, et al.. Two-pion Bose-Einstein correlations in pp collisions at sqrt(s)=900 GeV. Physical Review D, 2010, 82, pp.052001. ⟨10.1103/PhysRevD.82.052001⟩. ⟨in2p3-00498218⟩
  • K. Aamodt, N. Abel, U. Abeysekara, A. Abrahantes Quintana, A. Abramyan, et al.. Transverse momentum spectra of charged particles in proton-proton collisions at \sqrt{s} = 900~GeV with ALICE at the LHC. Physics Letters B, 2010, 693, pp.53-68. ⟨10.1016/j.physletb.2010.08.026⟩. ⟨in2p3-00498219⟩

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