Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J. Kopyra, H. Abdoul-Carime. Dissociation of gaseous zwitterion glycine-betaine by slow electrons. The Journal of Chemical Physics, 2010, 132, pp.204302. ⟨10.1063/1.3436718⟩. ⟨in2p3-00492921⟩
  • S. Chatrchyan, P. Nedelec, D. Sillou, M. Besancon, R. Chipaux, et al.. Commissioning and Performance of the CMS Silicon Strip Tracker with Cosmic Ray Muons. Journal of Instrumentation, 2010, 5(03), pp.T03008. ⟨10.1088/1748-0221/5/03/T03008⟩. ⟨in2p3-00664753⟩
  • S. Chatrchyan, P. Nedelec, D. Sillou, M. Besancon, R. Chipaux, et al.. Time Reconstruction and Performance of the CMS Electromagnetic Calorimeter. Journal of Instrumentation, 2010, 5(03), pp.T03011. ⟨10.1088/1748-0221/5/03/T03011⟩. ⟨in2p3-00664804⟩
  • J. Argyriades, R. Arnold, C. Augier, J. Baker, A. S. Barabash, et al.. Results of the BiPo-1 prototype for radiopurity measurements for the SuperNEMO double beta decay source foils. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2010, 622, pp.120-128. ⟨10.1016/j.nima.2010.07.037⟩. ⟨in2p3-00506430⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of direct photon pair production cross sections in ppbar collisions at sqrt(s)=1.96 TeV. Physics Letters B, 2010, 690, pp.108-117. ⟨10.1016/j.physletb.2010.05.017⟩. ⟨in2p3-00461181⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of the normalized Z/gamma*->mu+mu- transverse momentum distribution in p\bar{p} collisions at sqrt{s}=1.96 TeV. Physics Letters B, 2010, 693, pp.522-530. ⟨10.1016/j.physletb.2010.09.012⟩. ⟨in2p3-00489271⟩
  • C. Gaillard, I. Billard, O. Klimchuk, A. Ouadi, S. Georg. Solvatation et complexation du rhénium dans les liquides ioniques. Journées annuelles du GNR PARIS, 2010, Avignon, France. ⟨in2p3-01018519⟩
  • Francisco Chinesta, G. Regnier, M. R. Mackley. Modeling the Rheological Behavior of CNTs Suspensions. 45ème Colloque du Groupe Français de Rhéologie, 2010, Lyon, France. ⟨hal-01008458⟩
  • Siamak Niroomandi, I. Alfaro, Elías Cueto, Francisco Chinesta. Haptic Surgery Simulation Through Non-Linear Model Reduction Techniques. Seventh International Conference on Engineering Computational Technology, 2010, Valencia, Spain. ⟨hal-01008248⟩
  • K. Aamodt, Laurent Aphecetche, Guillaume Batigne, Z. Conesa del Valle, H. Delagrange, et al.. Elliptic flow of charged particles in Pb-Pb collisions at 2.76 TeV. Physical Review Letters, 2010, 105, pp.252302. ⟨10.1103/PhysRevLett.105.252302⟩. ⟨in2p3-00537767⟩

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