Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
546 documents

  • P. Manescu, H. Ladjal, Joseph Azencot, M. Beuve, E. Testa, et al.. 4D radiotherapeutic dose calculation using biomechanical respiratory motion description. International Journal of Computer Assisted Radiology and Surgery, 2014, 9 (3), pp.449-457. ⟨10.1007/s11548-013-0935-2⟩. ⟨hal-00949717⟩
  • M. Beuve. Theory Days on Advances in Biomolecule Irradiation. Theory Days on Advances in Biomolecule Irradiation, Nov 2013, Toulouse, France. ⟨hal-00994276⟩
  • Julie Constanzo. Développement de la plateforme Radiograaff d'irradiation protons pour des études en radiobiologie.. Physique Nucléaire Expérimentale [nucl-ex]. Université Claude Bernard - Lyon I, 2013. Français. ⟨NNT : ⟩. ⟨tel-00977357⟩
  • H. Ladjal, B. Shariat, Joseph Azencot, M. Beuve. Appropriate Biomechanics and kinematics Modeling of the respiratory System: Human Diaphragm and Thorax. IEEE/RSJ International Conference on Intelligent Robots and Systems, Nov 2013, Tokyo, Japan. pp.2004-2009, ⟨10.1109/IROS.2013.6696623⟩. ⟨hal-00850623⟩
  • J. Constanzo. Développement de la plateforme Radiograaff d'irradiation protons pour des études en radiobiologie. 2013. ⟨hal-00949679⟩
  • J. Constanzo, M. Fallavier, G. Alphonse, P. Battiston-Montagne, C. Bernard, et al.. RBE of two Human Head and Neck Squamous Carcinoma Cell lines irradiated by medium-energy protons of the Radiograaff platform. MICROS 2013, 16th International Symposium on Microdosimetry, Oct 2013, Trévise, Italy. ⟨hal-00906176⟩
  • Michael Beuve, Jean-Michel Moreau, Claire Rodriguez-Lafrasse, Etienne Testa. Biological systems: from water radiolysis to carbon ion radiotherapy. CIRIL, 30 years of interdisciplinary research at GANIL, Oct 2013, Caen, France. pp.012004, ⟨10.1088/1742-6596/629/1/012004⟩. ⟨hal-01179496⟩
  • J. Constanzo, M. Fallavier, G. Alphonse, P. Battiston-Montagne, C. Bernard, et al.. Radiograaff, une plateforme pour l'étude des effets biologiques induits par des ions: développements, dosimétrie et premières études. 11ème Colloque International de Radiobiologie Fondamentale et Appliquée (CIRFA) 2013, Oct 2013, La Grande Motte, France. ⟨hal-00906174⟩
  • X. Lojacono, M.-H. Richard, J.-L. Ley, E. Testa, C. Ray, et al.. Low Statistics Reconstruction of the Compton Camera Point Spread Function in 3D Prompt- \gamma Imaging of Ion Beam Therapy. IEEE Transactions on Nuclear Science, 2013, 60 (5), pp.3355 - 3363. ⟨10.1109/TNS.2013.2275200⟩. ⟨hal-00872700⟩
  • M. Beuve. Biological systems: from water radiolysis to carbon ion radiotherapy. 30 years of interdisciplinary research at GANIL, Oct 2013, Caen, France. ⟨hal-00994280⟩

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