Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Maurice Robert Kibler. THE IMPACT OF GIULIO RACAH ON CRYSTAL- AND LIGAND-FIELD THEORIES. International Conference in Commemoration of the Centenary of the Birth of G. Racah (1909-1965) - Zaragoza, Spain, 22-24 February 2010, Feb 2010, Zaragoza, Spain. pp.37-84. ⟨in2p3-00575948⟩
  • R. Kieffer. Development of a semi-digital hadronic calorimeter using GRPCs for future linear collider experiments. 12th International Vienna Conference on Instrumentation - VCI 2010, Feb 2010, Vienne, Austria. pp.328-331, ⟨10.1016/j.nima.2010.06.346⟩. ⟨in2p3-00594652⟩
  • Djamel Dabli. Utilisation d'un modèle microdosimétrique cinétique (MKM) pour l'interprétation d'irradiations cellulaires dans le cadre de l'hadronthérapie : Application de simulations Monte‐Carlo.. Biophysique [physics.bio-ph]. Université Blaise Pascal - Clermont-Ferrand II, 2010. Français. ⟨NNT : ⟩. ⟨tel-00504039⟩
  • F. Le Foulher, M. Bajard, M. Chevallier, D. Dauvergne, N. Freud, et al.. Monte Carlo simulations of prompt-gamma emission during carbon ion irradiation. Physics For Health in Europe, Feb 2010, Genève, Switzerland. ⟨in2p3-00778974⟩
  • G. Bruny, S. Feil, K. El-Farkh, C.G. Montano, H. Abdoul-Carime, et al.. Irradiation of Biomolecular Nanosystems with Fast Protons. XVIIth Symposium on Atomic Cluster and Surface Physics (SASP), Jan 2010, Obergugl, Austria. ⟨in2p3-00781014⟩
  • G. Bruny, S. Feil, K. El-Farkh, C.G. Montaño, H. Abdoul-Carime, et al.. Protonated molecular cluster for studies of radiation mechanisms. XVII Symposium on Atomic Cluster and Surface Physics 2010 (SASP 2010), Jan 2010, Obergurgl, Australia. ⟨in2p3-01059686⟩
  • W. Chen, W. Dong, M. Holovko, X. Chen. Comment on “A Highly Accurate and Analytic Equation of State for a Hard Sphere Fluid in Random Porous Media”. Journal of Physical Chemistry B, 2010, 114 (2), pp.1225 - 1225. ⟨10.1021/jp9106603⟩. ⟨hal-01889628⟩
  • L. Bois, F. Chassagneux, Y. Battie, F. Bessueille, L. Mollet, et al.. Chemical growth and photochromism of silver nanoparticles into a mesoporous titania template. Langmuir, 2010, 26 (2), pp.1199. ⟨10.1021/la902339j⟩. ⟨ujm-00416407⟩
  • M. Beuve. Modélisation des effets radiobiologiques : échelles d'espace et de temps. MELUSYN - SOLEIL conférence thématique, Jan 2010, Gif-sur-Yvette, France. ⟨in2p3-00777758⟩
  • R.A. Scalzo, C. Akerlof, G. Aldering, P. Antilogus, C. Aragon, et al.. Nearby Supernova Factory Observations of SN 2007if: Evidence for Shell Structure in the Explosion of a Super-Chandrasekhar-Mass White Dwarf. 215th Meeting of the American Astonomical Society, Jan 2010, Washington DC, United States. pp.450. ⟨in2p3-00589583⟩

Powered by HAL logo