Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J. Gascon. Dark Matter direct detection activities in France. 3rd France China Particle Physics Laboratory Workshop, Apr 2010, Lyon, France. ⟨in2p3-01011103⟩
  • R. Chehab. An hybrid positron source for ILC. 3rd France China Particle Physics Laboratory Workshop, Apr 2010, Lyon, France. ⟨in2p3-01011101⟩
  • D. Autiero. Development of a Front ASIC and a DAQ System for R&D large LAr TPC detectors for neutrino and astroparticle physics experiments. st International Workshop towards the Giant Liquid Argon Charge Imaging Experiment (GLA2010), Mar 2010, Tsukuba, Japan. ⟨in2p3-00772464⟩
  • N. Lumb. Progress towards a technological prototype for a semi-digital hadron calorimeter based on Glass RPCs. International Linear Collider Workshop, Mar 2010, Beijing, China. ⟨in2p3-00493641⟩
  • R. Bernhard, R. Field, R. Chierici, M. Cacciari, A. Moraes, et al.. Proceedings of the First International Workshop on Multiple Partonic Interactions at the LHC (MPI08). 2010. ⟨hal-00526768⟩
  • Y. Battie, N. Destouches, L. Bois, F. Chassagneux, N. Moncoffre, et al.. Generation of an ordered layer of silver nanoparticles in mesostructured dielectric films. Journal of Nanoparticle Research, 2010, 12, pp.1073-1082. ⟨10.1007/s11051-009-9794-8⟩. ⟨ujm-00428566⟩
  • F. Poirier, R. Chehab, O. Dadoun, P. Lepercq, A. Variola. SuperB positron production and capture. SuperB XII General Meeting, Mar 2010, Annecy Le Vieux, France. ⟨in2p3-00466246⟩
  • E. Gangler. SNfactory first results. 45th Rencontres de Moriond on Cosmology : the new challenges - Cosmology 2010, Mar 2010, La Tuile, Italy. ⟨in2p3-00696272⟩
  • C. Adloff, J. Blaha, J.-J. Blaising, M. Chefdeville, C. Drancourt, et al.. CALICE Report to the DESY Physics Research Committee. 2010. ⟨in2p3-00462509⟩
  • M. Beuve. Simulation of HO2 + O2 production by water radiolysis: Influence of various parameters. COST- MELUSYN Joint Meeting on Biomolecular Damages Induced by Low and High-Energy Radiations, Mar 2010, Paris, France. ⟨in2p3-00777473⟩

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