Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • F. Poirier, I. Chaikovska, O. Dadoun, P. Lepercq, R. Roux, et al.. Positron Production and Capture based on Low Energy Electrons for SuperB. 1st International Particle Accelerator Conference (IPAC 2010), May 2010, Kyoto, Japan. Joint Accelerator Conferences Website, pp.1650-1652, 2010. ⟨in2p3-00496524⟩
  • D. Boilley, Y. Lallouet, B. Yilmaz, Y. Abe. What can we learn from the fission of super-heavy elements?. 7th International Seminar devoted to New Experimental and Theoretical Achievements in Low-energy Fission, May 2010, Gent, Belgium. ⟨in2p3-00487178⟩
  • C. Ray, M. Bajard, J. Constanzo, M. Chevallier, D. Dauvergne, et al.. Dose monitoring in ion therapy by means of prompt radiation. 49th Annual Meeting of the Particle Therapy Co-Operative Group (PTCOG 49), May 2010, Tokyo, Japan. ⟨in2p3-00777466⟩
  • Jacques Saadé, Anne-Laure Didier, Pierre-Frédéric Villard, Romain Buttin, Jean-Michel Moreau, et al.. A Preliminary Study For A Biomechanical Model Of The Respiratory System. Engineering and Computational Sciences for Medical Imaging in Oncology - ECSMIO 2010, May 2010, Angers, France. pp.509-515. ⟨hal-00509817⟩
  • Sacha Davidson. "(Some Questions about) Lepton Flavour and Number Non-conservation and Other Exotica at NA62". NA62 Physics Book Workshop, May 2010, Genève, Switzerland. ⟨in2p3-00978630⟩
  • I. Laktineh. Construction of a technological semi-digital hadronic calorimeter using GRPC. XIV International Conference on Calorimetry in High Energy Physics (CALOR 2010), May 2010, Beijing, China. pp.012077, ⟨10.1088/1742-6596/293/1/012077⟩. ⟨in2p3-00691544⟩
  • Ad.R. Raduta, B. Borderie, E. Geraci, N. Le Neindre, P. Napolitani, et al.. Alpha-particle condensation in excited 12C. 2010. ⟨in2p3-00474410⟩
  • G. Bruny, S. Feil, K. El-Farkh, C.G. Montaño, H. Abdoul-Carime, et al.. Protonated mixed water clusters : new mass selected beams to study molecular interactions after irradiation. Collisions with Molecules and Clusters, Apr 2010, Milton Keynes, United Kingdom. ⟨in2p3-00781047⟩
  • I. Laktineh. Developpment of a semi-digital hadronic calorimeter for ILC. 3rd France China Particle Physics Laboratory Workshop, Apr 2010, Lyon, France. ⟨in2p3-01011100⟩
  • R. Chehab. An hybrid positron source for ILC. 3rd France China Particle Physics Laboratory Workshop, Apr 2010, Lyon, France. ⟨in2p3-01011101⟩

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