Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • A. Cazes. OPERA Electronic Detectors. Neutrino 2010, Jun 2010, Athènes, Greece. ⟨in2p3-00772506⟩
  • F. Roellinghoff, M.-H. Richard, M. Chevallier, J. Constanzo, D. Dauvergne, et al.. Design of a Compton camera for 3D prompt-γ imaging during ion beam therapy. Imaging 2010, International conference on imaging techniques in subatomic physics, astrophysics, medicine, biology and industry, Jun 2010, Stockholm, Sweden. pp.s20-s23, ⟨10.1016/j.nima.2011.01.069⟩. ⟨in2p3-00559943⟩
  • D. Contardo. The Compact Muon Solenoid first physics results. 12th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD10), Jun 2010, Sienne, Italy. pp.25-30, ⟨10.1016/j.nuclphysbps.2011.03.125⟩. ⟨in2p3-00610894⟩
  • F. Gieres. Path integrals in noncommutative quantum mechanics. Conference on Non Commutative and Non Relativistic Physics, Jun 2010, Tours, France. ⟨in2p3-00740596⟩
  • N. Wehbe, M. Fallavier, S. Della Negra, J. Depauw, A. Brunelle, et al.. Sputtering and secondary ion emission under gold cluster impact: Cluster size and velocity dependences of the yields. Desorption 2010, May 2010, Seillac, France. ⟨in2p3-00589526⟩
  • A. Bevan, M. Bona, M. Ciuchini, D. Derkach, E. Franco, et al.. Standard Model updates and new physics analysis with the Unitarity Triangle fit. 8th Conference on Flavor Physics and CP Violation 2010 (FPCP 2010), May 2010, Torino, Italy. 039 (8 p.). ⟨in2p3-00584175⟩
  • Ad.R. Raduta, B. Borderie, E. Geraci, N. Le Neindre, P. Napolitani, et al.. Production of \alpha-particle condensate states in heavy-ion collisions. 2nd Workshop on "State of the Art in Nuclear Cluster Physics" (SOTANCP2), May 2010, Bruxelles, Belgium. pp.902-905, ⟨10.1142/S0218301311018939⟩. ⟨in2p3-00515835⟩
  • D. Lebhertz, S. Courtin, F. Haas, D.G. Jenkins, M. Ciemala, et al.. Probing the 12C-12C and 12C-16O molecular states by radiative capture: present status and future. 2nd Workshop on "State of the Art in Nuclear Cluster Physics" (SOTANCP2), May 2010, Bruxelles, Belgium. pp.793-796, ⟨10.1142/S0218301311018691⟩. ⟨in2p3-00521508⟩
  • Edda Gschwendtner, Karel Cornelis, Ilias Efthymiopoulos, Alfredo Ferrari, Ans Pardons, et al.. Performance and Operational Experience of the CNGS Facility. 1st International Particle Accelerator Conference (IPAC'10), May 2010, Tokyo, Japan. ⟨in2p3-01019353⟩
  • O. Dadoun, I. Chaikovska, P. Lepercq, F. Poirier, A. Variola, et al.. The Baseline Positron Production and Capture Scheme for CLIC. 1st International Particle Accelerator Conference (IPAC 2010), May 2010, Kyoto, Japan. pp.2389-2391. ⟨in2p3-00496847⟩

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