Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • D. Dauvergne. Deceleration of Highly-Charged Ions in Crystal Channeling Conditions. 7th Stored Particle Atomic Physics Research Collaboration, Aug 2010, Lanzhou, China. ⟨in2p3-00777433⟩
  • P. Sortais, T. Lamy, J. Medard, J. Angot, C. Peaucelle. Beam, multi-beam and broad beamproduction with COMIC devices. XIXth International Workshop on ECR Ion Sources (ECRIS 2010), Aug 2010, Grenoble, France. pp.TUCOCK01. ⟨in2p3-00512352⟩
  • C. Peaucelle, J. Angot, P. Grandemange, T. Lamy, T. Thuillier, et al.. FIRST A/Q=3 BEAMS OF PHOENIX V2 ON THE HEAVY IONS LOW ENERGY BEAM TRANSPORT LINE OF SPIRAL2. XIXth International Workshop on ECR Ion Sources (ECRIS 2010), Aug 2010, Grenoble, France. pp.TUCOAK01. ⟨in2p3-00512348⟩
  • A. Vancraeyenest, D. Guinet, D. Curien, O. Stézowski, Q.T. Doan, et al.. \gamma-spectroscopy of positive parity bands in the Gd^{156} nucleus. 3rd International Conference on Frontiers in Nuclear Structure, Astrophysics and Reactions (FINUSTAR), Aug 2010, Rhodes, Greece. pp.453-455, ⟨10.1063/1.3628443⟩. ⟨in2p3-00785193⟩
  • D. Benjamin, M. Herndon, E. James, T. Junk, N. Krumnack, et al.. Combined CDF and D0 Upper Limits on Standard Model Higgs-Boson Production with up to 6.7 fb-1 of Data. 2010. ⟨in2p3-00508544⟩
  • N. Chanon. Photon commissioning in CMS at 7 TeV. Conference Higgs Hunting 2010, Jul 2010, Orsay, France. ⟨in2p3-00967588⟩
  • G. Lehaut. A Study of Stopping Power in Nuclear Reactions at Intermediate Energies. International Symposium on Nuclear Symmetry Energy (NuSym10), Jul 2010, Wako, Japan. ⟨in2p3-00765411⟩
  • A. Bevan, M. Bona, M. Ciuchini, D. Derkach, E. Franco, et al.. Update of the Unitarity Triangle Analysis. 35th International Conference on High Energy Physics (ICHEP2010), Jul 2010, Paris, France. 270 (4 p.). ⟨in2p3-00580427⟩
  • G. Grenier. Search for Leptoquarks and Technicolor at the Tevatron. 35th International Conference on High Energy Physics (ICHEP2010), Jul 2010, Paris, France. pp.391. ⟨in2p3-00612175⟩
  • J. Gascon. Dark Matter direct detection searches. 35th International Conference on High Energy Physics (ICHEP2010), Jul 2010, Paris, France. pp.539. ⟨in2p3-00612194⟩

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