Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • R. Tieulent. Performance du V0 en collisions pp dans ALICE. Rencontres QGP-France 2010, Sep 2010, Etretat, France. ⟨in2p3-00524248⟩
  • M. Kerschhaggl, G. Aldering, P. Antilogus, C. Aragon, S. Bailey, et al.. Cosmology with the Nearby Supernova Factory. Particle and Nuclear Astrophysics, International Workshop on Nuclear Physics, 32nd Course, Sep 2010, Erice, Sicily, Italy. pp.335-339, ⟨10.1016/J.PPNP.2011.01.030⟩. ⟨in2p3-00589232⟩
  • Fabienne Paulin, Daniel Guinet. L'enseignement de concept de "parentĂ©" au regard de la dĂ©marche expĂ©rimentale. AREF 2010 congrès international, Sep 2010, Genève, Suisse. https://plone.unige.ch/aref2010/communications-orales/premiers-auteurs-en-p/Lenseignement.pdf/view. ⟨hal-00976344⟩
  • G. Gutierrez, N. Toulhoat, N. Moncoffre, Y. Pipon, A. Perrat-Mabilon, et al.. Comportement thermique du Xe dans ZrC0,95O0,05. XIIèmes JournĂ©es Nationales de Radiochimie et Chimie NuclĂ©aire, Sep 2010, Lyon, France. ⟨in2p3-01018526⟩
  • C. Teyssier, J. Bouchami, F. Dallaire, J. Idárraga, C. Leroy, et al.. Performance of the Medipix and Timepix devices for the recognition of electron-gamma radiation fields. International Workshop on Semiconductor Pixel Detectors for Particles and Imaging 2010, Sep 2010, Grindelwald, Switzerland. pp.92-97, ⟨10.1016/j.nima.2010.12.114⟩. ⟨in2p3-00842349⟩
  • C. Smith. Rare K and B decays with non-standard missing energy. 6th International Workshop on the CKM Unitarity Triangle, CKM2010, Sep 2010, Warwick, United Kingdom. ⟨in2p3-00589207⟩
  • D. Lebhertz, M. CiemaĹ‚a, S. Courtin, A. Goasduff, D.G. Jenkins, et al.. Performances of the Future Multidetector PARIS Illustrated on the Radiative Capture Physics Case. Zakopane Conference on Nuclear physics "Extremes of the Nuclear Landscape", Aug 2010, Zakopane, Poland. pp.721-724, ⟨10.5506/APhysPolB.42.721⟩. ⟨in2p3-00578752⟩
  • C. A. de Sousa, Pedro Costa, M. C. Ruivo, H. Hansen. Phase diagram and critical properties in the Polyakov--Nambu--Jona-Lasinio model. IX International Conference on Quark Confinement and the Hadron Spectrum - QCHS IX, Aug 2010, Madrid, Spain. pp.592-594, ⟨10.1063/1.3575104⟩. ⟨in2p3-00589070⟩
  • K. HadyĹ„ska-KlÄ™k, P. J. Napiorkowski, A. Maj, F. Azaiez, J.J. Valiente-DobĂłn, et al.. Refinement of the 42Ca Level Scheme. Preliminary Results from the First AGATA Demonstrator Experiment. Zakopane conference on nuclear physics, Aug 2010, Zakopane, Poland. pp.817-824, ⟨10.5506/APhysPolB.42.817⟩. ⟨in2p3-00587825⟩
  • Y. Nakano, Y. Takano, T. Shindo, T. Ikeda, Y. Kanai, et al.. Observation of intrashell radiative decay of Li-like uranium (2p(3/2)-2s(1/2)) using silicon drift detectors. 15th International Conference on the Physics of Highly Charged Ions, Aug 2010, Shanghai, China. pp.014010, ⟨10.1088/0031-8949/2011/T144/014010⟩. ⟨in2p3-00685979⟩

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