Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. R. Kibler. Elements pour l'information quantique et le calcul quantique. Conference on Quantum Information and Related Topics, Oct 2010, Rabat, Morocco. ⟨in2p3-00740588⟩
  • A. Falkiewicz. Photon reconstruction with CMS. 4th International Conference on Hard and Electromagnetic Probes of High Energy Nuclear Collisions, Oct 2010, Eilat, Israel. ⟨in2p3-00967643⟩
  • Marc-Antoine Verdier. Scintillateurs cryogĂ©niques pour la dĂ©tection d'Ă©vĂ©nements rares, dans les expĂ©riences EDELWEISS et EURECA. Autre [cond-mat.other]. UniversitĂ© Claude Bernard - Lyon I, 2010. Français. ⟨NNT : 2010LYO10173⟩. ⟨tel-00556620v2⟩
  • Nicolas Chanon. Observation des photons directs dans les premières donnĂ©es et prĂ©paration Ă  la recherche du boson de Higgs dans l'expĂ©rience CMS au LHC (CERN). Physique [physics]. UniversitĂ© Claude Bernard - Lyon I, 2010. Français. ⟨NNT : ⟩. ⟨tel-00598989⟩
  • R. Chehab. POSIPOL: from polarized and unpolarized photons to positrons. 4th International Conference on Charged and Neutral Particles Channeling Phenomena "Channeling 2010", Oct 2010, Ferrara, Italy. pp.9-17, ⟨10.1393/ncc/i2011-10904-0⟩. ⟨in2p3-00650676⟩
  • X. Artru, I. Chaikovska, R. Chehab, M. Chevallier, O. Dadoun, et al.. Positron Sources using Channeling: a promising device for Linear Colliders. 4th International Conference on Charged and Neutral Particles Channeling Phenomena "Channeling 2010", Oct 2010, Ferrara, Italy. Societa Italiana di Fisica, 34, pp.141-148, 2011, ⟨10.1393/ncc/i2011-10902-2⟩. ⟨in2p3-00593589⟩
  • L. Rinolfi, R. Chehab, O. Dadoun, T. Kamitani, F. Poirier, et al.. Positron Source using Channelling for the Baseline of the CLIC study. 4th International Conference on Charged and Neutral Particles Channeling Phenomena "Channeling 2010", Oct 2010, Ferrara, Italy. ⟨in2p3-01011830⟩
  • X. Artru. Unitarity bound on the energy loss by a charged particle travelling near a periodic radiator. 4th International Conference Charged and Neutral Particles Channelin Phenomena - Channeling 2010, Oct 2010, Ferrara, Italy. pp.29-36, ⟨10.1393/ncc/i2011-10917-7⟩. ⟨in2p3-00672797⟩
  • D. Dauvergne, C. Ray, A. Bräuning-Demian, F. Bosch, H. Bräuning, et al.. Deceleration of H-like uranium ions in a crystal. 4th International Conference on Charged and Neutral Particles Channeling Phenomena "Channeling 2010", Oct 2010, Ferrara, Italy. ⟨in2p3-00777439⟩
  • C. Ray, M. Gouanère, D. Dauvergne, M. Bajard, R. Chehab, et al.. RICCE: Research of Internal Clock by Channeling of Electrons. Preliminary results at the LNF-BTF. 4th International Conference on Charged and Neutral Particles Channeling Phenomena "Channeling 2010", Oct 2010, Ferrara, Italy. ⟨in2p3-00777480⟩

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