Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
476 documents

  • M. Caron, H. Rothard, M. Toulemonde, B. Gervais, MichaĂ«l Beuve. Theoretical and experimental study of electronic temperatures in heavy ion tracks from Auger electron spectra and thermal spike calculations. Sixth Internaional Symposium on Swift Heavy Ions in Matter (SHIM 2005), May 2005, Aschaffenburg, Germany. pp.36-40, ⟨10.1016/j.nimb.2005.11.061⟩. ⟨in2p3-00416424⟩
  • A. L'Hoir, A. Adoui, F. BarruĂ©, A. Billebaud, F. Bosch, et al.. Ion slowing down and charge exchange at small impact parameters selected by channeling: superdensity effects. 6th International Symposium on Swift Heavy Ions in Matter SHIM 2005, May 2005, Aschaffenburg, Germany. pp.1-14, ⟨10.1016/j.nimb.2005.11.055⟩. ⟨in2p3-00025220⟩
  • N. Brambilla, M. Krämer, R. Mussa, A. Vairo, G. Bali, et al.. Heavy quarkonium physics. [Research Report] CERN–2005–005, CERN, Suisse. 2005, pp.1-487. ⟨in2p3-00023434⟩
  • Pierre-FrĂ©dĂ©ric Villard, MichaĂ«l Beuve, Behzad Shariat, Vincent Baudet, Fabrice Jaillet. Lung Mesh Generation to Simulate Breathing Motion with a Finite Element Method. Information Visualisation, 2004, London, United Kingdom. pp.194--199. ⟨hal-00849206⟩
  • H. Hamrita, E. Rauly, Y. Blumenfeld, B. Borderie, M. Chabot, et al.. Pulse shape discrimination with silicon detectors using charge and current-sensitive preamplifiers. International Workshop on Multifragmentation and Related Topics (IWM2003), Nov 2003, Caen, France. pp.149-152. ⟨in2p3-00023393⟩
  • Pierre-FrĂ©dĂ©ric Villard, MichaĂ«l Beuve, Behzad Shariat, Vincent Baudet, Fabrice Jaillet, et al.. Continous Media Mechanics simulation of Lung Motion.. 9th workshop on Heavy Charged Particles in Biology and Medicine, 2003, Lyon, France. ⟨hal-00849210⟩
  • D. Dauvergne, A. Belkacem, F. BarruĂ©, J.P. Bocquet, M. Chevallier, et al.. Measurement of vacuum-assisted photoionization at 1 GeV for Au and Ag targets. Physical Review Letters, 2003, 90, pp.153002. ⟨10.1103/PhysRevLett.90.153002⟩. ⟨in2p3-00013668⟩
  • D. Dauvergne, A. Bräuning-Demian, F. Bosch, H. Bräuning, M. Chevallier, et al.. Deceleration of highly charged heavy ions in a crystal. 2003, pp.108. ⟨in2p3-00024800⟩
  • Vincent Baudet, Pierre-FrĂ©dĂ©ric Villard, Fabrice Jaillet, MichaĂ«l Beuve, Behzad Shariat. Towards Accurate Tumour Tracking in Lungs. Information Visualisation, 2003, London, United Kingdom. pp.338--343. ⟨hal-00849207⟩
  • D. Dauvergne, A. Brauening-Demian, F. Bosch, H. Brauening, M. Chevallier, et al.. Impact parameter dependent electron capture by decelerated U^{91+} ions at 20 MeV/u using crystal channeling conditions. International Conference on Highly Charged Ions, Sep 2002, Caen, France. pp.773. ⟨in2p3-00013680⟩

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