Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V.M. Abazov, B. Abbott, B.S. Acharya, M. Adams, T. Adams, et al.. Search for resonant WW and WZ production in ppbar collisions at {\sqrt{s} = 1.96}TeV. Physical Review Letters, 2011, 107, pp.011801. ⟨10.1103/PhysRevLett.107.011801⟩. ⟨in2p3-00541186⟩
  • G. Gutierrez, N. Toulhoat, N. Moncoffre, Y. Pipon, N. Djourelov, et al.. High temperature annealing of Xe implanted ZrC0.95O0.05 investigated by RBS, TEM and PAS-DBS. E-MRS 2011 Spring Meeting, 2011, Strasbourg, France. pp.57-61, ⟨10.1016/j.pnucene.2011.10.007⟩. ⟨in2p3-00691819⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of the WZ\rightarrow \ell\nu\ell\ell cross section and limits on anomalous triple gauge couplings in p\bar{p} collisions at \sqrt{s} = 1.96 TeV. Physics Letters B, 2011, 695, pp.67-73. ⟨10.1016/j.physletb.2010.10.047⟩. ⟨in2p3-00489761⟩
  • V.M. Abazov, B. Abbott, B.S. Acharya, M. Adams, T. Adams, et al.. Search for single vectorlike quarks in ppbar collisions at sqrt(s) = 1.96 TeV. Physical Review Letters, 2011, 106, pp.081801. ⟨10.1103/PhysRevLett.106.081801⟩. ⟨in2p3-00524503⟩
  • Z. Ahmed, D. S. Akerib, E. Armengaud, S. Arrenberg, C. Augier, et al.. Combined Limits on WIMPs from the CDMS and EDELWEISS Experiments. Physical Review D, 2011, 84, pp.011102(R). ⟨10.1103/PhysRevD.84.011102⟩. ⟨in2p3-00593910⟩
  • B. Braunn, M. Labalme, G. Ban, M. Chevallier, J. Colin, et al.. Nuclear reaction measurements of 95MeV/u 12C interactions on PMMA for hadrontherapy. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2011, 269, pp.2676-2684. ⟨10.1016/j.nimb.2011.08.010⟩. ⟨in2p3-00619633⟩
  • P. Verdier. Some tevatron results and first BSM searches in CMS. Workshop on BSM and the early LHC, Dec 2010, Lyon, France. ⟨in2p3-01022476⟩
  • J. Llodra-Perez. Dark Matter from Lorentz Invariance in 6D: a LHC Friendly Scenario with a Natural LKP. BSM and the early LHC, Dec 2010, Lyon, France. ⟨in2p3-01022459⟩
  • Hervé Chanal, D. Contardo, Y. Zoccarato. A Front End Chip Development For The SLHC CMS Silicon Strip Tracker. 17th International Conference on Electronics, Circuits, and Systems (ICECS 2010), Dec 2010, Athènes, Greece. pp.942-945, ⟨10.1109/ICECS.2010.5724668⟩. ⟨in2p3-00560095⟩
  • M. Beuve, E. Testa. Hadronthérapie : vers une dosimétrie clinique. Journées de réflexion CNRS/IN2P3 des applications sociétales de la physique nucléaire : énergie et santé, Dec 2010, Saint-François, France. ⟨in2p3-00777491⟩

Powered by HAL logo