Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V.M. Abazov, M. Besançon, S. Chevalier-Théry, F. Couderc, A. Croc, et al.. Measurement of the ttbar production cross section using dilepton events in ppbar collisions. Physics Letters B, 2011, 704, pp.403-410. ⟨10.1016/j.physletb.2011.09.046⟩. ⟨in2p3-00596304⟩
  • V. Abazov, F. Badaud, Pascal Gay, Ph. Gris, G. Sajot, et al.. Search for first generation leptoquark pair production in the electron + missing energy + jets final state. Physical Review D, 2011, 84, pp.071104. ⟨10.1103/PhysRevD.84.071104⟩. ⟨in2p3-00608456⟩
  • S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Search for Physics Beyond the Standard Model in Opposite-Sign Dilepton Events in pp collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2011, 6, pp.026. ⟨10.1007/JHEP06(2011)026⟩. ⟨in2p3-00575029⟩
  • M. Childress, G. Aldering, C. Aragon, P. Antilogus, S. Bailey, et al.. Keck Observations of the Young Metal-Poor Host Galaxy of the Super-Chandrasekhar-Mass Type Ia Supernova SN 2007if. The Astrophysical Journal, 2011, 733, pp.3. ⟨10.1088/0004-637X/733/1/3⟩. ⟨in2p3-00610569⟩
  • V.M. Abazov, B. Abbott, B.S. Acharya, M. Adams, T. Adams, et al.. Measurement of the ZZ production cross section in p-pbar collisions at sqrt(s)=1.96 TeV. Physical Review D, 2011, 84, pp.011103(R). ⟨10.1103/PhysRevD.84.011103⟩. ⟨in2p3-00586604⟩
  • V.M. Abazov, B. Abbott, B.S. Acharya, M. Adams, T. Adams, et al.. Measurements of inclusive W+jets production rates as a function of jet transverse momentum in ppbar collisions at sqrt{s}=1.96 TeV. Physics Letters B, 2011, 705, pp.200-207. ⟨10.1016/j.physletb.2011.10.011⟩. ⟨in2p3-00599291⟩
  • V.M. Abazov, B. Abbott, B.S. Acharya, M. Adams, T. Adams, et al.. Precision measurement of the ratio B(t -> Wb)/B(t -> Wq) and extraction of Nutb. Physical Review Letters, 2011, 107, pp.121802. ⟨10.1103/PhysRevLett.107.121802⟩. ⟨in2p3-00604060⟩
  • V.M. Abazov, B. Abbott, B.S. Acharya, M. Adams, T. Adams, et al.. Bounds on an anomalous dijet resonance in W+jets production in ppbar collisions at sqrt{s} =1.96$ TeV. Physical Review Letters, 2011, 107, pp.011804. ⟨10.1103/PhysRevLett.107.011804⟩. ⟨in2p3-00600474⟩
  • J. Abdallah, P. Abreu, W. Adam, P. Adzic, T. Albrecht, et al.. A study of the b-quark fragmentation function with the DELPHI detector at LEP I and an averaged distribution obtained at the Z Pole. European Physical Journal C: Particles and Fields, 2011, 71, pp.1557. ⟨10.1140/epjc/s10052-011-1557-x⟩. ⟨in2p3-00569064⟩
  • H. Mathez, D. Dauvergne, Y. Zoccarato, Guo-Neng Lu, Shiming Deng. Front-end multi-channel PMT-associated readout chip for hodoscope application. 6th International Conference on New Developments in Photodetection (NDIP 2011), 2011, Lyon, France. pp.390-393, ⟨10.1016/j.nima.2011.11.042⟩. ⟨in2p3-00649655⟩

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