Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- V. Khachatryan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Strange Particle Production in pp Collisions at sqrt(s) = 0.9 and 7 TeV. Journal of High Energy Physics, 2011, 5, pp.064. ⟨10.1007/JHEP05(2011)064⟩. ⟨in2p3-00568735⟩
- S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Search for New Physics with a Mono-Jet and Missing Transverse Energy in pp Collisions at sqrt(s) = 7 TeV. Physical Review Letters, 2011, 107, pp.201804. ⟨10.1103/PhysRevLett.107.201804⟩. ⟨in2p3-00602993⟩
- S. Chatrchyan, D. Sillou, M. Besancon, S. Choudhury, M. Dejardin, et al.. Search for First Generation Scalar Leptoquarks in the evjj channel in pp collisions at sqrt(s) = 7 TeV. Physics Letters B, 2011, 703, pp.246-266. ⟨10.1016/j.physletb.2011.07.089⟩. ⟨in2p3-00596303⟩
- C. Ray, A. Bräuning-Demian, H. Bräuning, M. Chevallier, C. Cohen, et al.. Measurements of high energy loss rates of fast highly charged U ions channeled in thin silicon crystals. Physical Review B: Condensed Matter and Materials Physics (1998-2015), 2011, 84, pp.024119. ⟨10.1103/PhysRevB.84.024119⟩. ⟨in2p3-00609765⟩
- G. Cacciapaglia, R. Chierici, A. Deandrea, L. Panizzi, S. Perries, et al.. Four tops on the real projective plane at LHC. Journal of High Energy Physics, 2011, 1110, pp.042. ⟨10.1007/JHEP10(2011)042⟩. ⟨in2p3-00611260⟩
- V. M. Abazov, G. Grenier, T. Kurca, P. Lebrun, P. Verdier, et al.. Search for the Standard Model Higgs Boson in the H -> WW -> lepton+neutrino+q'qbar Decay Channel. Physical Review Letters, 2011, 106, pp.171802. ⟨10.1103/PhysRevLett.106.171802⟩. ⟨in2p3-00561659⟩
- D. Sillou, M. Besancon, M. Dejardin, D. Denegri, B. Fabbro, et al.. Search for Stopped Gluinos in pp collisions at sqrt s = 7 TeV. Physical Review Letters, 2011, 106, pp.011801. ⟨10.1103/PhysRevLett.106.011801⟩. ⟨in2p3-00540935⟩
- G. Cacciapaglia, A. Deandrea, J. Llodra-Perez. The Universal Real Projective Plane: LHC phenomenology at one Loop. Journal of High Energy Physics, 2011, 1110, pp.146. ⟨10.1007/JHEP10(2011)146⟩. ⟨in2p3-00589003⟩
- V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Determination of the width of the top quark. Physical Review Letters, 2011, 106, pp.022001. ⟨10.1103/PhysRevLett.106.022001⟩. ⟨in2p3-00522253⟩
- Mohammed Daoud, Maurice Robert Kibler. Phase operators, phase states and vector phase states for SU(3) and SU(2,1). Journal of Mathematical Physics, 2011, 52, pp.082101. ⟨10.1063/1.3620414⟩. ⟨in2p3-00587897⟩
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