Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- M. Beccaria, G. O. Dovier, G. Macorini, E. Mirabella, L. Panizzi, et al.. Semi-inclusive bottom-Higgs production at LHC: The complete one-loop electroweak effect in the MSSM. Physical Review D, 2011, 82, pp.093018. ⟨10.1103/PhysRevD.82.093018⟩. ⟨hal-00481134⟩
- P. Mertens, C. Smith. The s ---> d gamma decay in and beyond the Standard Model. Journal of High Energy Physics, 2011, 2011, pp.069. ⟨10.1007/JHEP08(2011)069⟩. ⟨in2p3-00589112⟩
- C.R. Mafra, O. Schlotter, S. Stieberger, D. Tsimpis. Six open string disk amplitude in pure spinor superspace. Nuclear Physics B, 2011, 846, pp.359-393. ⟨10.1016/j.nuclphysb.2011.01.008⟩. ⟨in2p3-00740203⟩
- K. Aamodt, A. Abrahantes Quintana, D. Adamova, A.M. Adare, M.M. Aggarwal, et al.. Suppression of Charged Particle Production at Large Transverse Momentum in Central Pb--Pb Collisions at
TeV. Physics Letters B, 2011, 696, pp.30-39. ⟨10.1016/j.physletb.2010.12.020⟩. ⟨in2p3-00544311⟩ - V.M. Abazov, B. Abbott, B.S. Acharya, M. Adams, T. Adams, et al.. Azimuthal decorrelations and multiple parton interactions in photon+2 jet and photon+3 jet events in ppbar collisions at sqrt{s}=1.96 TeV. Physical Review D, 2011, 83, pp.052008. ⟨10.1103/PhysRevD.83.052008⟩. ⟨in2p3-00553844⟩
- V.M. Abazov, B. Abbott, B.S. Acharya, M. Adams, T. Adams, et al.. Search for
associated production in 5.3 fb
of 
collisions at the Fermilab Tevatron. Physics Letters B, 2011, 698, pp.6-13. ⟨10.1016/j.physletb.2011.02.036⟩. ⟨in2p3-00544121⟩ - R. C. Thomas, G. Aldering, P. Antilogus, C. Aragon, S. Bailey, et al.. Type Ia Supernova Carbon Footprints. The Astrophysical Journal, 2011, 743, pp.27. ⟨10.1088/0004-637X/743/1/27⟩. ⟨in2p3-00632080⟩
- A. Arbey, M. Battaglia, F. Mahmoudi. Implications of LHC Searches on SUSY Particle Spectra: The pMSSM Phase Space with Neutralino Dark Matter. European Physical Journal C: Particles and Fields, 2011, 72, pp.1847. ⟨10.1140/epjc/s10052-011-1847-3⟩. ⟨in2p3-00633215⟩
- N. Djourelov, G. Gutierrez, H. Marinov, E. Popov, N. Toulhoat, et al.. Xe-implanted zirconium oxycarbide studied by variable energy positron beam. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2011, 269, pp.2709-2714. ⟨10.1016/j.nimb.2011.08.022⟩. ⟨in2p3-00661732⟩
- V.M. Abazov, B. Abbott, B.S. Acharya, M. Adams, T. Adams, et al.. Search for W'->tb resonances with left- and right-handed couplings to fermions. Physics Letters B, 2011, 699, pp.145-150. ⟨10.1016/j.physletb.2011.03.066⟩. ⟨in2p3-00551957⟩
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