Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • B. Li, R. ÉtĂ©, G. Grenier, I. Laktineh. APRIL : a novel Algorithm for Particle Reconstruction at ILC. 3rd Conference on Calorimetry for the High Energy Frontier, Nov 2019, Fukuoka, Japan. pp.C05016, ⟨10.1088/1748-0221/15/05/C05016⟩. ⟨hal-02504649⟩
    • ClĂ©mentine Panetier. Étude des mĂ©canismes de migration du cĂ©sium dans le dioxyde d'uranium stoechiomĂ©trique et sur-stoechiomĂ©trique : influence du molybdène. MatĂ©riaux. UniversitĂ© de Lyon, 2019. Français. ⟨NNT : 2019LYSE1248⟩. ⟨tel-02454477⟩
    • Yasmine Ali, Lucas Auzel, Caterina Monini, Jean Michel LĂ©tang, Etienne Testa, et al.. Simulations Monte Carlo de spectres microdosimĂ©triques, nanodosimĂ©triqes et d’espèces radiolytiques avec GEANT4-DNA et LPCHEM. JournĂ©es Mi2B/SFPM 2019, Nov 2019, Nantes, France. ⟨hal-02359553⟩
    • R. JimĂ©nez Estupiñán, P. Adzic, E. Auffray, D. Bailleux, D. Di Calafiori, et al.. The upgrade and re-validation of the Compact Muon Solenoid Electromagnetic Calorimeter Control and Safety Systems during the Second Long Shutdown of the Large Hadron Collider at CERN. 24th International Conference on Computing in High Energy and Nuclear Physics, Nov 2019, Adelaide, Australia. pp.01009, ⟨10.1051/epjconf/202024501009⟩. ⟨hal-03047593⟩
    • R. Barnett, S. J. Warren, D. J. Mortlock, J.-G. Cuby, C. Conselice, et al.. Euclid preparation. V. Predicted yield of redshift 7 < z < 9 quasars from the wide survey. Astronomy & Astrophysics - A&A, 2019, 631, pp.A85. ⟨10.1051/0004-6361/201936427⟩. ⟨cea-02334278⟩
    • Denis Dauvergne, L. Abbassi, Jean-François Adam, A. Bes, G. Bosson, et al.. Medical applications of diamond detectors: online control of Hadrontherapy with fast timing and Microbeam Radiation Therapy monitoring. JSPS-CNRS diamond detector workshop 2019, Oct 2019, Yuzawa city, Akita, Japan. ⟨hal-02382681⟩
    • C. Caplan, O. Allegrini, J. P. Cachemiche, B. Carlus, X. Chen, et al.. A ÎĽTCA back-end firmware for data acquisition and slow control of the CLaRyS Compton camera. NSS/MIC 2019 : IEEE Nuclear Science Symposium and Medical Imaging Conference, Oct 2019, Manchester, United Kingdom. ⟨10.1109/NSS/MIC42101.2019.9059941⟩. ⟨hal-02309672⟩
    • Ahmad Addoum, Nils Krah, Jean Michel LĂ©tang, Simon Rit. Proton scatter radiography with integration-mode detectors by exploiting the West-Sherwood effect. 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Oct 2019, Manchester, United Kingdom. ⟨hal-03126835⟩
    • X. Chen, O. Allegrini, B. Carlus, C. Caplan, L. Caponetto, et al.. A Time-Of-Flight Gamma Camera Data Acquisition System for Hadrontherapy Monitoring. NSS/MIC 2019 : IEEE Nuclear Science Symposium and Medical Imaging Conference, Oct 2019, Manchester, United Kingdom. pp.1-3, ⟨10.1109/NSS/MIC42101.2019.9060072⟩. ⟨hal-02309735⟩
    • J. Livingstone, A. Etxebeste, S. Curtoni, D. Dauvergne, M. Fontana, et al.. Ultra fast prompt-gamma imaging for the online monitoring of the ion range in hadron therapy. NSS/MIC 2019 : IEEE Nuclear Science Symposium and Medical Imaging Conference, Oct 2019, Manchester, United Kingdom. ⟨hal-02309773⟩

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